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Calcineurin/NFAT inhibitors maintain cognition in a preclinical prevention study in an aging canine model of Alzheimer disease.
Sordo L, Ubele MF, Boaz KA, Mefford JL, Jones ED, McCarty KL, van Rooyen HY, Smiley J, Bembenek Bailey SA, Perpich JA, Meacham B, Powell DK, Bresch F, Crump JW, Phelan MJ, Noche JA, Stark CE, Puskás LG, Norris CM, Head E. Sordo L, et al. Among authors: smiley j. Neurobiol Aging. 2025 Feb;146:1-14. doi: 10.1016/j.neurobiolaging.2024.11.003. Epub 2024 Nov 10. Neurobiol Aging. 2025. PMID: 39547056
Age-Related Brain Atrophy and the Positive Effects of Behavioral Enrichment in Middle-Aged Beagles.
Noche JA, Radhakrishnan H, Ubele MF, Boaz K, Mefford JL, Jones ED, van Rooyen HY, Perpich JA, McCarty K, Meacham B, Smiley J, Bembenek Bailey SA, Puskás LG, Powell DK, Sordo L, Phelan MJ, Norris CM, Head E, Stark CEL. Noche JA, et al. Among authors: smiley j. J Neurosci. 2024 May 15;44(20):e2366232024. doi: 10.1523/JNEUROSCI.2366-23.2024. J Neurosci. 2024. PMID: 38561226 Free PMC article.
Increased neuronal expression of the early endosomal adaptor APPL1 leads to endosomal and synaptic dysfunction with cholinergic neurodegeneration.
Jiang Y, Sachdeva K, Goulbourne CN, Berg MJ, Peddy J, Stavrides PH, Pensalfini A, Pawlik M, Whyte L, Balapal BS, Shivakumar S, Bleiwas C, Smiley JF, Mathews PM, Nixon RA. Jiang Y, et al. Among authors: smiley jf. bioRxiv [Preprint]. 2024 Sep 20:2024.09.19.613736. doi: 10.1101/2024.09.19.613736. bioRxiv. 2024. PMID: 39345644 Free PMC article. Preprint.
Inducible nitric oxide synthase (iNOS) is necessary for GBP-mediated T. gondii restriction in murine macrophages via vacuole nitration and intravacuolar network collapse.
Zhao XY, Lempke SL, Urbán Arroyo JC, Yin B, Holness NK, Smiley J, Ewald SE. Zhao XY, et al. Among authors: smiley j. bioRxiv [Preprint]. 2023 Jul 25:2023.07.24.549965. doi: 10.1101/2023.07.24.549965. bioRxiv. 2023. Update in: Nat Commun. 2024 Mar 27;15(1):2698. doi: 10.1038/s41467-024-46790-y PMID: 37546987 Free PMC article. Updated. Preprint.
367 results