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SF3B1 thermostability as an assay for splicing inhibitor interactions.
Amorello AN, Chandrashekar Reddy G, Melillo B, Cravatt BF, Ghosh AK, Jurica MS. Amorello AN, et al. Among authors: melillo b. J Biol Chem. 2024 Dec 24:108135. doi: 10.1016/j.jbc.2024.108135. Online ahead of print. J Biol Chem. 2024. PMID: 39725033 Free article.
Systematic in vitro evolution in Plasmodium falciparum reveals key determinants of drug resistance.
Luth MR, Godinez-Macias KP, Chen D, Okombo J, Thathy V, Cheng X, Daggupati S, Davies H, Dhingra SK, Economy JM, Edgar RCS, Gomez-Lorenzo MG, Istvan ES, Jado JC, LaMonte GM, Melillo B, Mok S, Narwal SK, Ndiaye T, Ottilie S, Palomo Diaz S, Park H, Peña S, Rocamora F, Sakata-Kato T, Small-Saunders JL, Summers RL, Tumwebaze PK, Vanaerschot M, Xia G, Yeo T, You A, Gamo FJ, Goldberg DE, Lee MCS, McNamara CW, Ndiaye D, Rosenthal PJ, Schreiber SL, Serra G, De Siqueira-Neto JL, Skinner-Adams TS, Uhlemann AC, Kato N, Lukens AK, Wirth DF, Fidock DA, Winzeler EA. Luth MR, et al. Among authors: melillo b. Science. 2024 Nov 29;386(6725):eadk9893. doi: 10.1126/science.adk9893. Epub 2024 Nov 29. Science. 2024. PMID: 39607932
Covalent targeting of splicing in T cells.
Scott KA, Kojima H, Ropek N, Warren CD, Zhang TL, Hogg SJ, Sanford H, Webster C, Zhang X, Rahman J, Melillo B, Cravatt BF, Lyu J, Abdel-Wahab O, Vinogradova EV. Scott KA, et al. Among authors: melillo b. Cell Chem Biol. 2024 Nov 22:S2451-9456(24)00445-8. doi: 10.1016/j.chembiol.2024.10.010. Online ahead of print. Cell Chem Biol. 2024. PMID: 39591969
Coordinated inheritance of extrachromosomal DNAs in cancer cells.
Hung KL, Jones MG, Wong IT, Curtis EJ, Lange JT, He BJ, Luebeck J, Schmargon R, Scanu E, Brückner L, Yan X, Li R, Gnanasekar A, Chamorro González R, Belk JA, Liu Z, Melillo B, Bafna V, Dörr JR, Werner B, Huang W, Cravatt BF, Henssen AG, Mischel PS, Chang HY. Hung KL, et al. Among authors: melillo b. Nature. 2024 Nov;635(8037):201-209. doi: 10.1038/s41586-024-07861-8. Epub 2024 Nov 6. Nature. 2024. PMID: 39506152 Free PMC article.
Redirecting the pioneering function of FOXA1 with covalent small molecules.
Won SJ, Zhang Y, Reinhardt CJ, Hargis LM, MacRae NS, DeMeester KE, Njomen E, Remsberg JR, Melillo B, Cravatt BF, Erb MA. Won SJ, et al. Among authors: melillo b. Mol Cell. 2024 Nov 7;84(21):4125-4141.e10. doi: 10.1016/j.molcel.2024.09.024. Epub 2024 Oct 15. Mol Cell. 2024. PMID: 39413792
An allosteric cyclin E-CDK2 site mapped by paralog hopping with covalent probes.
Zhang Y, Liu Z, Hirschi M, Brodsky O, Johnson E, Won SJ, Nagata A, Bezwada D, Petroski MD, Majmudar JD, Niessen S, VanArsdale T, Gilbert AM, Hayward MM, Stewart AE, Nager AR, Melillo B, Cravatt BF. Zhang Y, et al. Among authors: melillo b. Nat Chem Biol. 2024 Sep 18. doi: 10.1038/s41589-024-01738-7. Online ahead of print. Nat Chem Biol. 2024. PMID: 39294320
63 results