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Deep phenotypic profiling of neuroactive drugs in larval zebrafish.
Gendelev L, Taylor J, Myers-Turnbull D, Chen S, McCarroll MN, Arkin MR, Kokel D, Keiser MJ. Gendelev L, et al. Among authors: kokel d. Nat Commun. 2024 Nov 17;15(1):9955. doi: 10.1038/s41467-024-54375-y. Nat Commun. 2024. PMID: 39551797 Free PMC article.
A non-hallucinogenic psychedelic analogue with therapeutic potential.
Cameron LP, Tombari RJ, Lu J, Pell AJ, Hurley ZQ, Ehinger Y, Vargas MV, McCarroll MN, Taylor JC, Myers-Turnbull D, Liu T, Yaghoobi B, Laskowski LJ, Anderson EI, Zhang G, Viswanathan J, Brown BM, Tjia M, Dunlap LE, Rabow ZT, Fiehn O, Wulff H, McCorvy JD, Lein PJ, Kokel D, Ron D, Peters J, Zuo Y, Olson DE. Cameron LP, et al. Among authors: kokel d. Nature. 2021 Jan;589(7842):474-479. doi: 10.1038/s41586-020-3008-z. Epub 2020 Dec 9. Nature. 2021. PMID: 33299186 Free PMC article.
Identification of Psychoplastogenic N,N-Dimethylaminoisotryptamine (isoDMT) Analogues through Structure-Activity Relationship Studies.
Dunlap LE, Azinfar A, Ly C, Cameron LP, Viswanathan J, Tombari RJ, Myers-Turnbull D, Taylor JC, Grodzki AC, Lein PJ, Kokel D, Olson DE. Dunlap LE, et al. Among authors: kokel d. J Med Chem. 2020 Feb 13;63(3):1142-1155. doi: 10.1021/acs.jmedchem.9b01404. Epub 2020 Jan 24. J Med Chem. 2020. PMID: 31977208 Free PMC article.
Zebrafish behavioural profiling identifies GABA and serotonin receptor ligands related to sedation and paradoxical excitation.
McCarroll MN, Gendelev L, Kinser R, Taylor J, Bruni G, Myers-Turnbull D, Helsell C, Carbajal A, Rinaldi C, Kang HJ, Gong JH, Sello JK, Tomita S, Peterson RT, Keiser MJ, Kokel D. McCarroll MN, et al. Among authors: kokel d. Nat Commun. 2019 Sep 9;10(1):4078. doi: 10.1038/s41467-019-11936-w. Nat Commun. 2019. PMID: 31501447 Free PMC article.
σ1 receptor ligands control a switch between passive and active threat responses.
Rennekamp AJ, Huang XP, Wang Y, Patel S, Lorello PJ, Cade L, Gonzales AP, Yeh JR, Caldarone BJ, Roth BL, Kokel D, Peterson RT. Rennekamp AJ, et al. Among authors: kokel d. Nat Chem Biol. 2016 Jul;12(7):552-8. doi: 10.1038/nchembio.2089. Epub 2016 May 30. Nat Chem Biol. 2016. PMID: 27239788 Free PMC article.
Zebrafish behavioral profiling identifies multitarget antipsychotic-like compounds.
Bruni G, Rennekamp AJ, Velenich A, McCarroll M, Gendelev L, Fertsch E, Taylor J, Lakhani P, Lensen D, Evron T, Lorello PJ, Huang XP, Kolczewski S, Carey G, Caldarone BJ, Prinssen E, Roth BL, Keiser MJ, Peterson RT, Kokel D. Bruni G, et al. Among authors: kokel d. Nat Chem Biol. 2016 Jul;12(7):559-66. doi: 10.1038/nchembio.2097. Epub 2016 May 30. Nat Chem Biol. 2016. PMID: 27239787 Free PMC article.
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