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Systemic inhibition of de novo purine biosynthesis prevents weight gain and improves metabolic health by increasing thermogenesis and decreasing food intake.
Myers JW, Park WY, Eddie AM, Shinde AB, Prasad P, Murphy AC, Leonard MZ, Pinette JA, Rampy JJ, Montufar C, Shaikh Z, Hickman TT, Reynolds GN, Winn NC, Lantier L, Peck SH, Coate KC, Stein RW, Carrasco N, Calipari ES, McReynolds MR, Zaganjor E. Myers JW, et al. Among authors: rampy jj. bioRxiv [Preprint]. 2024 Nov 1:2024.10.28.620705. doi: 10.1101/2024.10.28.620705. bioRxiv. 2024. PMID: 39553975 Free PMC article. Preprint.