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Page 1
Cellular cartography reveals mouse prostate organization and determinants of castration resistance.
Cho H, Zhang Y, Tien JC, Mannan R, Luo J, Narayanan SP, Mahapatra S, Hu J, Shelley G, Cruz G, Shahine M, Wang L, Su F, Wang R, Cao X, Dhanasekaran SM, Keller ET, Pitchiaya S, Chinnaiyan AM. Cho H, et al. Among authors: chinnaiyan am. bioRxiv [Preprint]. 2024 Dec 27:2024.12.27.630532. doi: 10.1101/2024.12.27.630532. bioRxiv. 2024. PMID: 39763898 Free PMC article. Preprint.
Spatial Transcriptomics of IPMN Reveals Divergent Indolent and Malignant Lineages.
Iyer MK, Fletcher A, Shi C, Chen F, Kanu E, Eckhoff AM, Bao M, Frankel TL, Chinnaiyan AM, Nussbaum DP, Allen PJ. Iyer MK, et al. Among authors: chinnaiyan am. bioRxiv [Preprint]. 2024 Nov 3:2024.10.29.620810. doi: 10.1101/2024.10.29.620810. bioRxiv. 2024. PMID: 39554015 Free PMC article. Preprint.
The UBA1-STUB1 axis mediates cancer immune escape and resistance to checkpoint blockade.
Bao Y, Cruz G, Zhang Y, Qiao Y, Mannan R, Hu J, Yang F, Gondal M, Shahine M, Kang S, Mahapatra S, Chu A, Choi JE, Yu J, Lin H, Miner SJ, Robinson DR, Wu YM, Zheng Y, Cao X, Su F, Wang R, Hosseini N, Cieslik M, Kryczek I, Vaishampayan U, Zou W, Chinnaiyan AM. Bao Y, et al. Among authors: chinnaiyan am. Cancer Discov. 2024 Nov 14. doi: 10.1158/2159-8290.CD-24-0435. Online ahead of print. Cancer Discov. 2024. PMID: 39540840
Discovery of the first selective and potent PROTAC degrader for the pseudokinase TRIB2.
Wen C, Gajjala PR, Liu Y, Chen B, Bal MS, Sutaria P, Yuanyuan Q, Zheng Y, Zhou Y, Zhang J, Huang W, Ren X, Wang Z, Ding K, Chinnaiyan AM, Zhou F. Wen C, et al. Among authors: chinnaiyan am. Eur J Med Chem. 2025 Jan 5;281:117016. doi: 10.1016/j.ejmech.2024.117016. Epub 2024 Nov 1. Eur J Med Chem. 2025. PMID: 39520729
Corrigendum to "Androgen receptor degraders overcome common resistance mechanisms developed during prostate cancer treatment" [Neoplasia, Volume 22, Issue 2 (2020) 111-119].
Kregel S, Wang C, Han X, Xiao L, Fernandez-Salas E, Bawa P, McCollum BL, Wilder-Romans K, Apel IJ, Cao X, Speers C, Wang S, Chinnaiyan AM. Kregel S, et al. Among authors: chinnaiyan am. Neoplasia. 2024 Nov;57:101064. doi: 10.1016/j.neo.2024.101064. Epub 2024 Sep 28. Neoplasia. 2024. PMID: 39389678 Free article. No abstract available.
Discovery of ZLC491 as a Potent, Selective, and Orally Bioavailable CDK12/13 PROTAC Degrader.
Zhou L, Zhou K, Chang Y, Yang J, Fan B, Su Y, Li Z, Mannan R, Mahapatra S, Ding M, Zhou F, Huang W, Ren X, Xu J, Wang GX, Zhang J, Wang Z, Chinnaiyan AM, Ding K. Zhou L, et al. Among authors: chinnaiyan am. J Med Chem. 2024 Oct 24;67(20):18247-18264. doi: 10.1021/acs.jmedchem.4c01596. Epub 2024 Oct 10. J Med Chem. 2024. PMID: 39388374 Free PMC article.
CDK12 loss drives prostate cancer progression, transcription-replication conflicts, and synthetic lethality with paralog CDK13.
Tien JC, Luo J, Chang Y, Zhang Y, Cheng Y, Wang X, Yang J, Mannan R, Mahapatra S, Shah P, Wang XM, Todd AJ, Eyunni S, Cheng C, Rebernick RJ, Xiao L, Bao Y, Neiswender J, Brough R, Pettitt SJ, Cao X, Miner SJ, Zhou L, Wu YM, Labanca E, Wang Y, Parolia A, Cieslik M, Robinson DR, Wang Z, Feng FY, Chou J, Lord CJ, Ding K, Chinnaiyan AM. Tien JC, et al. Among authors: chinnaiyan am. Cell Rep Med. 2024 Oct 15;5(10):101758. doi: 10.1016/j.xcrm.2024.101758. Epub 2024 Oct 4. Cell Rep Med. 2024. PMID: 39368479 Free PMC article.
Development of an orally bioavailable CDK12/13 degrader and induction of synthetic lethality with AKT pathway inhibition.
Chang Y, Wang X, Yang J, Tien JC, Mannan R, Cruz G, Zhang Y, Vo JN, Magnuson B, Mahapatra S, Cho H, Dhanasekaran SM, Wang C, Wang Z, Zhou L, Zhou K, Zhou Y, Zhang P, Huang W, Xiao L, Liu WR, Hamadeh R, Su F, Wang R, Miner SJ, Cao X, Cheng Y, Mehra R, Ding K, Chinnaiyan AM. Chang Y, et al. Among authors: chinnaiyan am. Cell Rep Med. 2024 Oct 15;5(10):101752. doi: 10.1016/j.xcrm.2024.101752. Epub 2024 Sep 30. Cell Rep Med. 2024. PMID: 39353441 Free PMC article.
648 results