SOD1 mediates lysosome-to-mitochondria communication and its dysregulation by amyloid-β oligomers.
Norambuena A, Sun X, Wallrabe H, Cao R, Sun N, Pardo E, Shivange N, Wang DB, Post LA, Ferris HA, Hu S, Periasamy A, Bloom GS.
Norambuena A, et al.
Neurobiol Dis. 2022 Jul;169:105737. doi: 10.1016/j.nbd.2022.105737. Epub 2022 Apr 20.
Neurobiol Dis. 2022.
PMID: 35452786
Free PMC article.
We previously discovered Nutrient-induced Mitochondrial Activity (NiMA), an inter-organelle signaling pathway where nutrient-stimulated lysosomal mTORC1 activity regulates mtDNA replication in neurons by a mechanism sensitive to amyloid-beta oligomers (AbetaOs), a p …
We previously discovered Nutrient-induced Mitochondrial Activity (NiMA), an inter-organelle signaling pathway where nutrient-stimulated lyso …