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Mitochondrial NADK2-dependent NADPH controls Tau oligomer uptake in human neurons.
Pardo E, Kim T, Wallrabe H, Zengeler KE, Sagar VK, Mingledorff G, Sun X, Periasamy A, Lukens JR, Bloom GS, Norambuena A. Pardo E, et al. Among authors: norambuena a. bioRxiv [Preprint]. 2024 Nov 1:2024.10.31.621392. doi: 10.1101/2024.10.31.621392. bioRxiv. 2024. PMID: 39554169 Free PMC article. Preprint.
Structural and functional damage to neuronal nuclei caused by extracellular tau oligomers.
Sun X, Eastman G, Shi Y, Saibaba S, Oliveira AK, Lukens JR, Norambuena A, Mandell JW, Bloom GS. Sun X, et al. Among authors: norambuena a. bioRxiv [Preprint]. 2023 May 8:2023.05.08.539873. doi: 10.1101/2023.05.08.539873. bioRxiv. 2023. Update in: Alzheimers Dement. 2024 Mar;20(3):1656-1670. doi: 10.1002/alz.13535 PMID: 37214909 Free PMC article. Updated. Preprint.
Disrupted mitochondrial response to nutrients is a presymptomatic event in the cortex of the APP SAA knock-in mouse model of Alzheimer's disease.
Norambuena A, Sagar VK, Wang Z, Raut P, Feng Z, Wallrabe H, Pardo E, Kim T, Alam SR, Hu S, Periasamy A, Bloom GS. Norambuena A, et al. bioRxiv [Preprint]. 2024 Feb 4:2024.02.02.578668. doi: 10.1101/2024.02.02.578668. bioRxiv. 2024. Update in: Alzheimers Dement. 2024 Oct;20(10):6844-6859. doi: 10.1002/alz.14144 PMID: 38352486 Free PMC article. Updated. Preprint.
Dysregulation of mTOR by tau in Alzheimer's disease.
Bloom GS, Norambuena A. Bloom GS, et al. Among authors: norambuena a. Cytoskeleton (Hoboken). 2024 Jan;81(1):30-34. doi: 10.1002/cm.21782. Epub 2023 Aug 28. Cytoskeleton (Hoboken). 2024. PMID: 37638691 Free PMC article. Review.
SOD1 mediates lysosome-to-mitochondria communication and its dysregulation by amyloid-β oligomers.
Norambuena A, Sun X, Wallrabe H, Cao R, Sun N, Pardo E, Shivange N, Wang DB, Post LA, Ferris HA, Hu S, Periasamy A, Bloom GS. Norambuena A, et al. Neurobiol Dis. 2022 Jul;169:105737. doi: 10.1016/j.nbd.2022.105737. Epub 2022 Apr 20. Neurobiol Dis. 2022. PMID: 35452786 Free PMC article.
We previously discovered Nutrient-induced Mitochondrial Activity (NiMA), an inter-organelle signaling pathway where nutrient-stimulated lysosomal mTORC1 activity regulates mtDNA replication in neurons by a mechanism sensitive to amyloid-beta oligomers (AbetaOs), a p …
We previously discovered Nutrient-induced Mitochondrial Activity (NiMA), an inter-organelle signaling pathway where nutrient-stimulated lyso …
41 results