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ZEB2 drives intra-tumor heterogeneity and skin squamous cell carcinoma formation with distinct EMP transition states.
Verstappe J, Skrypek N, De Coninck J, Soen B, Taminau J, Tatari M, Bruneel K, Loret N, De Clercq K, Van den Broecke C, Van De Vijver K, Van Dorpe J, Haigh J, De Craene B, Goossens S, Vandamme N, Berx G. Verstappe J, et al. Among authors: bruneel k. iScience. 2024 Oct 16;27(11):111169. doi: 10.1016/j.isci.2024.111169. eCollection 2024 Nov 15. iScience. 2024. PMID: 39555401 Free PMC article.
Triple Therapy for Cystic Fibrosis Phe508del-Gating and -Residual Function Genotypes.
Barry PJ, Mall MA, Álvarez A, Colombo C, de Winter-de Groot KM, Fajac I, McBennett KA, McKone EF, Ramsey BW, Sutharsan S, Taylor-Cousar JL, Tullis E, Ahluwalia N, Jun LS, Moskowitz SM, Prieto-Centurion V, Tian S, Waltz D, Xuan F, Zhang Y, Rowe SM, Polineni D; VX18-445-104 Study Group. Barry PJ, et al. N Engl J Med. 2021 Aug 26;385(9):815-825. doi: 10.1056/NEJMoa2100665. N Engl J Med. 2021. PMID: 34437784 Free PMC article. Clinical Trial.
The EMT Transcription Factor ZEB2 Promotes Proliferation of Primary and Metastatic Melanoma While Suppressing an Invasive, Mesenchymal-Like Phenotype.
Vandamme N, Denecker G, Bruneel K, Blancke G, Akay Ö, Taminau J, De Coninck J, De Smedt E, Skrypek N, Van Loocke W, Wouters J, Nittner D, Köhler C, Darling DS, Cheng PF, Raaijmakers MIG, Levesque MP, Mallya UG, Rafferty M, Balint B, Gallagher WM, Brochez L, Huylebroeck D, Haigh JJ, Andries V, Rambow F, Van Vlierberghe P, Goossens S, van den Oord JJ, Marine JC, Berx G. Vandamme N, et al. Among authors: bruneel k. Cancer Res. 2020 Jul 15;80(14):2983-2995. doi: 10.1158/0008-5472.CAN-19-2373. Epub 2020 Jun 5. Cancer Res. 2020. PMID: 32503808