Li YX - Search Results

1

Enantiomeric C-6 fluorinated swainsonine derivatives as highly selective and potent inhibitors of α-mannosidase and α-l-rhamnosidase: Design, synthesis and structure-activity relationship study.

Gao FT, Zhang M, Shimadate Y, Kato A, Li YX, Jia YM, Yu CY. Gao FT, et al. Among authors: li yx. Eur J Med Chem. 2025 Jan 15;282:117031. doi: 10.1016/j.ejmech.2024.117031. Epub 2024 Nov 12. Eur J Med Chem. 2025. PMID: 39556895

2

Synthesis and glycosidase inhibition of 5-C-alkyl-DNJ and 5-C-alkyl-l-ido-DNJ derivatives.

Lu TT, Shimadate Y, Cheng B, Kanekiyo U, Kato A, Wang JZ, Li YX, Jia YM, Fleet GWJ, Yu CY. Lu TT, et al. Among authors: li yx. Eur J Med Chem. 2021 Nov 15;224:113716. doi: 10.1016/j.ejmech.2021.113716. Epub 2021 Jul 22. Eur J Med Chem. 2021. PMID: 34340042

3

Design, synthesis and glycosidase inhibition of C-4 branched LAB and DAB derivatives.

Wang JZ, Cheng B, Kato A, Kise M, Shimadate Y, Jia YM, Li YX, Fleet GWJ, Yu CY. Wang JZ, et al. Among authors: li yx. Eur J Med Chem. 2022 Apr 5;233:114230. doi: 10.1016/j.ejmech.2022.114230. Epub 2022 Feb 25. Eur J Med Chem. 2022. PMID: 35255314

4

Diastereoselective Synthesis, Glycosidase Inhibition, and Docking Study of C-7-Fluorinated Casuarine and Australine Derivatives.

Li YX, Wang JZ, Shimadate Y, Kise M, Kato A, Jia YM, Fleet GWJ, Yu CY. Li YX, et al. J Org Chem. 2022 Jun 3;87(11):7291-7307. doi: 10.1021/acs.joc.2c00485. Epub 2022 May 18. J Org Chem. 2022. PMID: 35584209

5

trans, trans-2-C-Aryl-3,4-dihydroxypyrrolidines as potent and selective β-glucosidase inhibitors: Pharmacological chaperones for Gaucher disease.

Wang JZ, Shimadate Y, Kise M, Kato A, Jia YM, Li YX, Fleet GWJ, Yu CY. Wang JZ, et al. Among authors: li yx. Eur J Med Chem. 2022 Aug 5;238:114499. doi: 10.1016/j.ejmech.2022.114499. Epub 2022 May 29. Eur J Med Chem. 2022. PMID: 35675756

6

C-6 fluorinated casuarines as highly potent and selective amyloglucosidase inhibitors: Synthesis and structure-activity relationship study.

Li YX, Wang JZ, Shimadate Y, Kise M, Kato A, Jia YM, Fleet GWJ, Yu CY. Li YX, et al. Eur J Med Chem. 2022 Dec 15;244:114852. doi: 10.1016/j.ejmech.2022.114852. Epub 2022 Oct 21. Eur J Med Chem. 2022. PMID: 36332547

7

Nanomolar β-glucosidase and β-galactosidase inhibition by enantiomeric α-1-C-alkyl-1,4-dideoxy-1,4-imino-arabinitol derivatives.

Zi D, Song YY, Lu TT, Kise M, Kato A, Wang JZ, Jia YM, Li YX, Fleet GWJ, Yu CY. Zi D, et al. Among authors: li yx. Eur J Med Chem. 2023 Feb 5;247:115056. doi: 10.1016/j.ejmech.2022.115056. Epub 2022 Dec 28. Eur J Med Chem. 2023. PMID: 36603505

8

Design, synthesis and glycosidase inhibition of DAB derivatives with C-4 peptide and dipeptide branches.

Zi D, Shimadate Y, Wang JZ, Kato A, Li YX, Jia YM, Fleet GWJ, Yu CY. Zi D, et al. Among authors: li yx. Org Biomol Chem. 2023 Mar 29;21(13):2729-2741. doi: 10.1039/d3ob00097d. Org Biomol Chem. 2023. PMID: 36916165

9

Design and synthesis of iso-allo-DNJ and L-isoDALDP derivatives: pursuit of potent and selective inhibitors of α-glucosidase.

Yang LF, Zhang M, Shimadate Y, Kato A, Hou TL, Li YX, Jia YM, Fleet GWJ, Yu CY. Yang LF, et al. Among authors: li yx. Org Biomol Chem. 2023 Apr 26;21(16):3453-3464. doi: 10.1039/d3ob00404j. Org Biomol Chem. 2023. PMID: 37039337

10

Design and synthesis of 6-C-alkyl-DMDP type nanomolar inhibitors of β-galactosidase and β-glucosidase based on broussonetine S and related derivatives.

Gao FT, Wu QK, Zhang M, Shimadate Y, Qian G, Song YY, Kato A, Li YX, Jia YM, Fleet GWJ, Yu CY. Gao FT, et al. Among authors: li yx. Eur J Med Chem. 2024 Sep 5;275:116570. doi: 10.1016/j.ejmech.2024.116570. Epub 2024 Jun 6. Eur J Med Chem. 2024. PMID: 38878517

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