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Delayed low-dose oral administration of 4'-fluorouridine inhibits pathogenic arenaviruses in animal models of lethal disease.
Welch SR, Spengler JR, Westover JB, Bailey KW, Davies KA, Aida-Ficken V, Bluemling GR, Boardman KM, Wasson SR, Mao S, Kuiper DL, Hager MW, Saindane MT, Andrews MK, Krueger RE, Sticher ZM, Jung KH, Chatterjee P, Shrivastava-Ranjan P, Lo MK, Coleman-McCray JD, Sorvillo TE, Genzer SC, Scholte FEM, Kelly JA, Jenks MH, McMullan LK, Albariño CG, Montgomery JM, Painter GR, Natchus MG, Kolykhalov AA, Gowen BB, Spiropoulou CF, Flint M. Welch SR, et al. Among authors: gowen bb. Sci Transl Med. 2024 Nov 20;16(774):eado7034. doi: 10.1126/scitranslmed.ado7034. Epub 2024 Nov 20. Sci Transl Med. 2024. PMID: 39565871
Modeling Heartland virus disease in mice and therapeutic intervention with 4'-fluorouridine.
Westover JB, Jung KH, Alkan C, Boardman KM, Van Wettere AJ, Martens C, Rojas I, Hicks P, Thomas AJ, Saindane MT, Bluemling GR, Mao S, Kolykhalov AA, Natchus MG, Bates P, Painter GR, Ikegami T, Gowen BB. Westover JB, et al. Among authors: gowen bb. J Virol. 2024 Apr 16;98(4):e0013224. doi: 10.1128/jvi.00132-24. Epub 2024 Mar 21. J Virol. 2024. PMID: 38511932 Free PMC article.
86 results