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Page 1
Discovery of CHF-6523, an Inhaled Selective PI3Kδ Inhibitor for the Treatment of Chronic Obstructive Pulmonary Disease.
Bruno P, Pala D, Micoli A, Corsi M, Accetta A, Carzaniga L, Ronchi P, Fiorelli C, Formica M, Pizzirani D, Mazzucato R, Guariento S, Bertolini S, Martucci C, Allen AD, Mileo V, Capacchi S, Gallo PM, Fioni A, Xanxo Fernandez S, Villetti G, Puccini P, Civelli M, Guala M, Retini M, Martinelli P, Visentini F, Pavoni V, Daldosso M, Fontana S, Biagetti M, Capelli AM. Bruno P, et al. Among authors: pizzirani d. J Med Chem. 2024 Dec 5. doi: 10.1021/acs.jmedchem.4c02062. Online ahead of print. J Med Chem. 2024. PMID: 39635891
Quantum Hall effect in a CVD-grown oxide.
Zheliuk O, Kreminska Y, Fu Q, Pizzirani D, Ammerlaan ELQN, Wang Y, Hameed S, Wan P, Peng X, Wiedmann S, Liu Z, Ye J, Zeitler U. Zheliuk O, et al. Among authors: pizzirani d. Nat Commun. 2024 Nov 20;15(1):10052. doi: 10.1038/s41467-024-54014-6. Nat Commun. 2024. PMID: 39567480 Free PMC article.
Design, Synthesis, and Activity of a Novel Series of Pyridazine-Based ALK5 Inhibitors.
Pala D, Ronchi P, Rescigno D, Bertani B, Capelli AM, Guariento S, Marchini G, Milioli M, Cesari N, Federico G, Grandi A, Stellari FF, Fernandez SX, Pappani A, Venturi L, Biagetti M, Civelli M, Semeraro T, Bianchi F, Trist IML, Remelli R, Armani E, Pizzirani D. Pala D, et al. Among authors: pizzirani d. ACS Med Chem Lett. 2024 Oct 23;15(11):1925-1932. doi: 10.1021/acsmedchemlett.4c00374. eCollection 2024 Nov 14. ACS Med Chem Lett. 2024. PMID: 39563792
Designing Soluble PROTACs: Strategies and Preliminary Guidelines.
García Jiménez D, Rossi Sebastiano M, Vallaro M, Mileo V, Pizzirani D, Moretti E, Ermondi G, Caron G. García Jiménez D, et al. Among authors: pizzirani d. J Med Chem. 2022 Oct 13;65(19):12639-12649. doi: 10.1021/acs.jmedchem.2c00201. Epub 2022 Apr 25. J Med Chem. 2022. PMID: 35469399 Free PMC article.
Discovery and SAR Evolution of Pyrazole Azabicyclo[3.2.1]octane Sulfonamides as a Novel Class of Non-Covalent N-Acylethanolamine-Hydrolyzing Acid Amidase (NAAA) Inhibitors for Oral Administration.
Di Fruscia P, Carbone A, Bottegoni G, Berti F, Giacomina F, Ponzano S, Pagliuca C, Fiasella A, Pizzirani D, Ortega JA, Nuzzi A, Tarozzo G, Mengatto L, Giampà R, Penna I, Russo D, Romeo E, Summa M, Bertorelli R, Armirotti A, Bertozzi SM, Reggiani A, Bandiera T, Bertozzi F. Di Fruscia P, et al. Among authors: pizzirani d. J Med Chem. 2021 Sep 23;64(18):13327-13355. doi: 10.1021/acs.jmedchem.1c00575. Epub 2021 Sep 1. J Med Chem. 2021. PMID: 34469137 Free PMC article.
Lead Optimization of Benzoxazolone Carboxamides as Orally Bioavailable and CNS Penetrant Acid Ceramidase Inhibitors.
Di Martino S, Tardia P, Cilibrasi V, Caputo S, Mazzonna M, Russo D, Penna I, Realini N, Margaroli N, Migliore M, Pizzirani D, Ottonello G, Bertozzi SM, Armirotti A, Nguyen D, Sun Y, Bongarzone ER, Lansbury P, Liu M, Skerlj R, Scarpelli R. Di Martino S, et al. Among authors: pizzirani d. J Med Chem. 2020 Apr 9;63(7):3634-3664. doi: 10.1021/acs.jmedchem.9b02004. Epub 2020 Mar 26. J Med Chem. 2020. PMID: 32176488 Free PMC article.
Second-Generation Non-Covalent NAAA Inhibitors are Protective in a Model of Multiple Sclerosis.
Migliore M Dr, Pontis S Dr, Fuentes de Arriba AL, Realini N, Torrente E, Armirotti A, Romeo E, Di Martino S, Russo D, Pizzirani D, Summa M, Lanfranco M, Ottonello G, Busquet P, Jung KM, Garcia-Guzman M, Heim R, Scarpelli R, Piomelli D. Migliore M Dr, et al. Among authors: pizzirani d. Angew Chem Int Ed Engl. 2016 Sep 5;55(37):11193-11197. doi: 10.1002/anie.201603746. Epub 2016 Jul 12. Angew Chem Int Ed Engl. 2016. PMID: 27404798 Free PMC article.
Potent α-amino-β-lactam carbamic acid ester as NAAA inhibitors. Synthesis and structure-activity relationship (SAR) studies.
Nuzzi A, Fiasella A, Ortega JA, Pagliuca C, Ponzano S, Pizzirani D, Bertozzi SM, Ottonello G, Tarozzo G, Reggiani A, Bandiera T, Bertozzi F, Piomelli D. Nuzzi A, et al. Among authors: pizzirani d. Eur J Med Chem. 2016 Mar 23;111:138-59. doi: 10.1016/j.ejmech.2016.01.046. Epub 2016 Jan 27. Eur J Med Chem. 2016. PMID: 26866968 Free article.
29 results