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Page 1
Cephalopod-inspired jetting devices for gastrointestinal drug delivery.
Arrick G, Sticker D, Ghazal A, Lu Y, Duncombe T, Gwynne D, Mouridsen B, Wainer J, Jepsen JPH, Last TS, Schultz D, Hess K, Medina De Alba E, Min S, Poulsen M, Anker C, Karandikar P, Pedersen HD, Collins J, Egecioglu NE, Tamang S, Cleveland C, Ishida K, Uhrenfeldt AH, Kuosmanen J, Pereverzina M, Hayward A, Kirk RK, You S, Dalsgaard CM, Gunnarsson SB, Patsi I, Bohr A, Azzarello A, Frederiksen MR, Herskind P, Li J, Roxhed N, Rahbek UL, Water JJ, Buckley ST, Traverso G. Arrick G, et al. Among authors: kirk rk. Nature. 2024 Dec;636(8042):481-487. doi: 10.1038/s41586-024-08202-5. Epub 2024 Nov 20. Nature. 2024. PMID: 39567682 Free PMC article.
Oral delivery of systemic monoclonal antibodies, peptides and small molecules using gastric auto-injectors.
Abramson A, Frederiksen MR, Vegge A, Jensen B, Poulsen M, Mouridsen B, Jespersen MO, Kirk RK, Windum J, Hubálek F, Water JJ, Fels J, Gunnarsson SB, Bohr A, Straarup EM, Ley MWH, Lu X, Wainer J, Collins J, Tamang S, Ishida K, Hayward A, Herskind P, Buckley ST, Roxhed N, Langer R, Rahbek U, Traverso G. Abramson A, et al. Among authors: kirk rk. Nat Biotechnol. 2022 Jan;40(1):103-109. doi: 10.1038/s41587-021-01024-0. Epub 2021 Aug 30. Nat Biotechnol. 2022. PMID: 34462588 Free PMC article.
An ingestible self-orienting system for oral delivery of macromolecules.
Abramson A, Caffarel-Salvador E, Khang M, Dellal D, Silverstein D, Gao Y, Frederiksen MR, Vegge A, Hubálek F, Water JJ, Friderichsen AV, Fels J, Kirk RK, Cleveland C, Collins J, Tamang S, Hayward A, Landh T, Buckley ST, Roxhed N, Rahbek U, Langer R, Traverso G. Abramson A, et al. Among authors: kirk rk. Science. 2019 Feb 8;363(6427):611-615. doi: 10.1126/science.aau2277. Science. 2019. PMID: 30733413 Free PMC article.
Gastrointestinal Device-Mediated Delivery of mRNA-Lipid Nanoparticles Achieves Distinct Expression and Biodistribution in Mice and Pigs.
Schultz D, Kempen PJ, Primdahl S, Pereverzina M, Uhrenfeldt AH, Alba EMD, Andreasen J, Pedersen HD, Cleveland C, Duncombe T, Ahnfelt-Ro Nne J, Kirk RK, Pfander IB, Sticker D, Water JJ, Buckley ST, Andresen TL, Urquhart AJ. Schultz D, et al. Among authors: kirk rk. ACS Appl Mater Interfaces. 2024 Dec 11;16(49):67192-67202. doi: 10.1021/acsami.4c11819. Epub 2024 Dec 2. ACS Appl Mater Interfaces. 2024. PMID: 39621822
Myocardial Changes in Diabetic and Nondiabetic Nonhuman Primates.
Krog S, Ludvigsen TP, Nielsen OL, Kirk RK, Lykkegaard K, Wulff EM, Møller JE, Pedersen HD, Olsen LH. Krog S, et al. Among authors: kirk rk. Vet Pathol. 2020 Mar;57(2):332-343. doi: 10.1177/0300985820901332. Epub 2020 Feb 25. Vet Pathol. 2020. PMID: 32096447
Diet-Dependent Changes of the DNA Methylome Using a Göttingen Minipig Model for Obesity.
Feng Y, Cirera S, Taşöz E, Liu Y, Olsen LH, Christoffersen BØ, Pedersen HD, Ludvigsen TP, Kirk RK, Schumacher-Petersen C, Deng Y, Fredholm M, Gao F. Feng Y, et al. Among authors: kirk rk. Front Genet. 2021 Mar 11;12:632859. doi: 10.3389/fgene.2021.632859. eCollection 2021. Front Genet. 2021. PMID: 33777102 Free PMC article.
Transcellular stomach absorption of a derivatized glucagon-like peptide-1 receptor agonist.
Buckley ST, Bækdal TA, Vegge A, Maarbjerg SJ, Pyke C, Ahnfelt-Rønne J, Madsen KG, Schéele SG, Alanentalo T, Kirk RK, Pedersen BL, Skyggebjerg RB, Benie AJ, Strauss HM, Wahlund PO, Bjerregaard S, Farkas E, Fekete C, Søndergaard FL, Borregaard J, Hartoft-Nielsen ML, Knudsen LB. Buckley ST, et al. Among authors: kirk rk. Sci Transl Med. 2018 Nov 14;10(467):eaar7047. doi: 10.1126/scitranslmed.aar7047. Sci Transl Med. 2018. PMID: 30429357 Clinical Trial.
Choline-deficient, high-fat diet-induced MASH in Göttingen Minipigs: characterization and effects of a chow reversal period.
Hvid H, Hjuler ST, Bedossa P, Tiniakos DG, Kamzolas I, Harder LM, Xue Y, Perfield JW, Kirk RK, Latta M, Mikkelsen LF, Pedersen HD; LITMUS Investigators. Hvid H, et al. Among authors: kirk rk. Am J Physiol Gastrointest Liver Physiol. 2024 Oct 1;327(4):G571-G585. doi: 10.1152/ajpgi.00120.2024. Epub 2024 Jul 23. Am J Physiol Gastrointest Liver Physiol. 2024. PMID: 39041677 Free PMC article.
32 results