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Acute myeloid leukemia drug tolerant persister cells survive chemotherapy by transiently increasing plasma membrane rigidity, that also increases their sensitivity to immune cell killing.
Morgenstern Y, Lee J, Na Y, Lieng BY, Ly NS, Gwynne WD, Hurren R, Ma L, Ling D, Gronda M, Arruda A, Frisch A, Zuckerman T, Ofran Y, Minden MD, Zhang L, O'Brien C, Quaile AT, Montenegro-Burke JR, Schimmer AD. Morgenstern Y, et al. Among authors: ma l. Haematologica. 2024 Nov 21. doi: 10.3324/haematol.2024.286018. Online ahead of print. Haematologica. 2024. PMID: 39568440 Free article.
Discovery of IRAK1/4/pan-FLT3 Kinase Inhibitors as Treatments for Acute Myeloid Leukemia.
Hoyt SB, Finocchio CJ, Croll E, Tawa GJ, Li H, Ma L, Li K, Liu L, Li R, Zhang X, Wilson K, Xu X, Shah P, Williams J, Fang Y, Bolanos LC, Gracia-Maldonado G, Kolt A, Robinson C, Free J, Edmondson EF, Difilippantonio S, Jones LM, Culver-Cochran AE, Rosenbaum JS, Starczynowski DT, Thomas CJ. Hoyt SB, et al. Among authors: ma l. ACS Med Chem Lett. 2024 Oct 23;15(11):1843-1851. doi: 10.1021/acsmedchemlett.4c00269. eCollection 2024 Nov 14. ACS Med Chem Lett. 2024. PMID: 39563805 Free PMC article.
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