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Page 1
Acid-exposed and hypoxic cancer cells do not overlap but are interdependent for unsaturated fatty acid resources.
Głowacka K, Ibanez S, Renoult O, Vermonden P, Giolito MV, Özkan K, Degavre C, Aubert L, Guilbaud C, Laloux-Morris F, Richiardone E, Ambroise J, Bouzin C, Brusa D, Dehairs J, Swinnen J, Corbet C, Larondelle Y, Feron O. Głowacka K, et al. Among authors: swinnen j. Nat Commun. 2024 Nov 21;15(1):10107. doi: 10.1038/s41467-024-54435-3. Nat Commun. 2024. PMID: 39572570 Free PMC article.
Saturated fatty acids induce NLRP3 activation in human macrophages through K+ efflux resulting from phospholipid saturation and Na, K-ATPase disruption.
Gianfrancesco MA, Dehairs J, L'homme L, Herinckx G, Esser N, Jansen O, Habraken Y, Lassence C, Swinnen JV, Rider MH, Piette J, Paquot N, Legrand-Poels S. Gianfrancesco MA, et al. Among authors: swinnen jv. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Jul;1864(7):1017-1030. doi: 10.1016/j.bbalip.2019.04.001. Epub 2019 Apr 4. Biochim Biophys Acta Mol Cell Biol Lipids. 2019. PMID: 30953761
Lipid droplet degradation by autophagy connects mitochondria metabolism to Prox1-driven expression of lymphatic genes and lymphangiogenesis.
Meçe O, Houbaert D, Sassano ML, Durré T, Maes H, Schaaf M, More S, Ganne M, García-Caballero M, Borri M, Verhoeven J, Agrawal M, Jacobs K, Bergers G, Blacher S, Ghesquière B, Dewerchin M, Swinnen JV, Vinckier S, Soengas MS, Carmeliet P, Noël A, Agostinis P. Meçe O, et al. Among authors: swinnen jv. Nat Commun. 2022 May 19;13(1):2760. doi: 10.1038/s41467-022-30490-6. Nat Commun. 2022. PMID: 35589749 Free PMC article.
The gluconeogenesis enzyme PCK2 has a non-enzymatic role in proteostasis in endothelial cells.
de Zeeuw P, Treps L, García-Caballero M, Harjes U, Kalucka J, De Legher C, Brepoels K, Peeters K, Vinckier S, Souffreau J, Bouché A, Taverna F, Dehairs J, Talebi A, Ghesquière B, Swinnen J, Schoonjans L, Eelen G, Dewerchin M, Carmeliet P. de Zeeuw P, et al. Among authors: swinnen j. Commun Biol. 2024 May 23;7(1):618. doi: 10.1038/s42003-024-06186-6. Commun Biol. 2024. PMID: 38783087 Free PMC article.
Lipid availability determines fate of skeletal progenitor cells via SOX9.
van Gastel N, Stegen S, Eelen G, Schoors S, Carlier A, Daniëls VW, Baryawno N, Przybylski D, Depypere M, Stiers PJ, Lambrechts D, Van Looveren R, Torrekens S, Sharda A, Agostinis P, Lambrechts D, Maes F, Swinnen JV, Geris L, Van Oosterwyck H, Thienpont B, Carmeliet P, Scadden DT, Carmeliet G. van Gastel N, et al. Nature. 2020 Mar;579(7797):111-117. doi: 10.1038/s41586-020-2050-1. Epub 2020 Feb 26. Nature. 2020. PMID: 32103177 Free PMC article.
Lipid degradation promotes prostate cancer cell survival.
Itkonen HM, Brown M, Urbanucci A, Tredwell G, Ho Lau C, Barfeld S, Hart C, Guldvik IJ, Takhar M, Heemers HV, Erho N, Bloch K, Davicioni E, Derua R, Waelkens E, Mohler JL, Clarke N, Swinnen JV, Keun HC, Rekvig OP, Mills IG. Itkonen HM, et al. Among authors: swinnen jv. Oncotarget. 2017 Jun 13;8(24):38264-38275. doi: 10.18632/oncotarget.16123. Oncotarget. 2017. PMID: 28415728 Free PMC article.
Corrigendum to "Concurrent MEK and autophagy inhibition is required to restore cell death associated danger-signalling in Vemurafenib-resistant melanoma cells" [Biochem. Pharmacol. 93 (3) (2015) 290-304].
Martin S, Dudek-Perić AM, Maes H, Garg AD, Gabrysiak M, Demirsoy S, Swinnen JV, Agostinis P. Martin S, et al. Among authors: swinnen jv. Biochem Pharmacol. 2020 May;175:113810. doi: 10.1016/j.bcp.2020.113810. Epub 2020 Feb 19. Biochem Pharmacol. 2020. PMID: 32085947 No abstract available.
268 results