Schafer CT - Search Results

1

Constitutive activity of an atypical chemokine receptor revealed by inverse agonistic nanobodies.

Perez Almeria CV, Otun O, Schlimgen R, Lamme TD, Crudden C, Youssef N, Musli L, Jenjak S, Bobkov V, Drube J, Hoffmann C, Volkman BF, Granier S, Bechara C, Siderius M, Heukers R, Schafer CT, Smit MJ. Perez Almeria CV, et al. Among authors: schafer ct. bioRxiv [Preprint]. 2024 Nov 4:2024.11.04.621790. doi: 10.1101/2024.11.04.621790. bioRxiv. 2024. PMID: 39574661 Free PMC article. Preprint.

2

Atypical Chemokine Receptor 3 'Senses' CXC Chemokine Receptor 4 Activation Through GPCR Kinase Phosphorylation.

Schafer CT, Chen Q, Tesmer JJG, Handel TM. Schafer CT, et al. bioRxiv [Preprint]. 2023 Mar 10:2023.02.25.530029. doi: 10.1101/2023.02.25.530029. bioRxiv. 2023. Update in: Mol Pharmacol. 2023 Oct;104(4):174-186. doi: 10.1124/molpharm.123.000710 PMID: 36865154 Free PMC article. Updated. Preprint.

3

ACKR3-arrestin2/3 complexes reveal molecular consequences of GRK-dependent barcoding.

Chen Q, Schafer CT, Mukherjee S, Gustavsson M, Agrawal P, Yao XQ, Kossiakoff AA, Handel TM, Tesmer JJG. Chen Q, et al. Among authors: schafer ct. bioRxiv [Preprint]. 2023 Jul 19:2023.07.18.549504. doi: 10.1101/2023.07.18.549504. bioRxiv. 2023. PMID: 37502840 Free PMC article. Preprint.

4

Distinct Activation Mechanisms of CXCR4 and ACKR3 Revealed by Single-Molecule Analysis of their Conformational Landscapes.

Schafer CT, Pauszek RF 3rd, Gustavsson M, Handel TM, Millar DP. Schafer CT, et al. bioRxiv [Preprint]. 2024 Jun 20:2023.10.31.564925. doi: 10.1101/2023.10.31.564925. bioRxiv. 2024. PMID: 37961571 Free PMC article. Preprint.

5

Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias.

Yen YC, Schafer CT, Gustavsson M, Eberle SA, Dominik PK, Deneka D, Zhang P, Schall TJ, Kossiakoff AA, Tesmer JJG, Handel TM. Yen YC, et al. Among authors: schafer ct. Sci Adv. 2022 Jul 15;8(28):eabn8063. doi: 10.1126/sciadv.abn8063. Epub 2022 Jul 13. Sci Adv. 2022. PMID: 35857509 Free PMC article.

6

Atypical Chemokine Receptor 3 "Senses" CXC Chemokine Receptor 4 Activation Through GPCR Kinase Phosphorylation.

Schafer CT, Chen Q, Tesmer JJG, Handel TM. Schafer CT, et al. Mol Pharmacol. 2023 Oct;104(4):174-186. doi: 10.1124/molpharm.123.000710. Epub 2023 Jul 20. Mol Pharmacol. 2023. PMID: 37474305 Free PMC article.

7

Novel fluorescent GPCR biosensor detects retinal equilibrium binding to opsin and active G protein and arrestin signaling conformations.

Schafer CT, Shumate A, Farrens DL. Schafer CT, et al. J Biol Chem. 2020 Dec 18;295(51):17486-17496. doi: 10.1074/jbc.RA120.014631. J Biol Chem. 2020. PMID: 33453993 Free PMC article.

8

Crystal structure of a natural light-gated anion channelrhodopsin.

Li H, Huang CY, Govorunova EG, Schafer CT, Sineshchekov OA, Wang M, Zheng L, Spudich JL. Li H, et al. Among authors: schafer ct. Elife. 2019 Jan 7;8:e41741. doi: 10.7554/eLife.41741. Elife. 2019. PMID: 30614787 Free PMC article.

9

Decay of an active GPCR: Conformational dynamics govern agonist rebinding and persistence of an active, yet empty, receptor state.

Schafer CT, Fay JF, Janz JM, Farrens DL. Schafer CT, et al. Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):11961-11966. doi: 10.1073/pnas.1606347113. Epub 2016 Oct 4. Proc Natl Acad Sci U S A. 2016. PMID: 27702898 Free PMC article.

10

Conformational selection and equilibrium governs the ability of retinals to bind opsin.

Schafer CT, Farrens DL. Schafer CT, et al. J Biol Chem. 2015 Feb 13;290(7):4304-18. doi: 10.1074/jbc.M114.603134. Epub 2014 Dec 1. J Biol Chem. 2015. PMID: 25451936 Free PMC article.

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