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DNA repair and anti-cancer mechanisms in the long-lived bowhead whale.
Firsanov D, Zacher M, Tian X, Sformo TL, Zhao Y, Tombline G, Lu JY, Zheng Z, Perelli L, Gurreri E, Zhang L, Guo J, Korotkov A, Volobaev V, Biashad SA, Zhang Z, Heid J, Maslov A, Sun S, Wu Z, Gigas J, Hillpot E, Martinez J, Lee M, Williams A, Gilman A, Hamilton N, Haseljic E, Patel A, Straight M, Miller N, Ablaeva J, Tam LM, Couderc C, Hoopman M, Moritz R, Fujii S, Hayman DJ, Liu H, Cai Y, Leung AKL, Simons MJP, Zhang Z, Nelson CB, Abegglen LM, Schiffman JD, Gladyshev VN, Modesti M, Genovese G, Vijg J, Seluanov A, Gorbunova V. Firsanov D, et al. Among authors: leung akl. bioRxiv [Preprint]. 2024 Nov 5:2023.05.07.539748. doi: 10.1101/2023.05.07.539748. bioRxiv. 2024. PMID: 39574710 Free PMC article. Preprint.
PARP1 condensates differentially partition DNA repair proteins and enhance DNA ligation.
Sang CC, Moore G, Tereshchenko M, Nosella ML, Zhang H, Alderson TR, Dasovich M, Leung A, Finkelstein IJ, Forman-Kay JD, Lee HO. Sang CC, et al. bioRxiv [Preprint]. 2024 Jan 22:2024.01.20.575817. doi: 10.1101/2024.01.20.575817. bioRxiv. 2024. Update in: EMBO Rep. 2024 Dec;25(12):5635-5666. doi: 10.1038/s44319-024-00285-5 PMID: 38328070 Free PMC article. Updated. Preprint.
Global remodeling of ADP-ribosylation by PARP1 suppresses influenza A virus infection.
Zhang Z, Uribe I, Davis KA, McPherson RL, Larson GP, Badiee M, Tran V, Ledwith MP, Feltman E, Yú S, Caì Y, Chang CY, Yang X, Ma Z, Chang P, Kuhn JH, Leung AKL, Mehle A. Zhang Z, et al. Among authors: leung akl. bioRxiv [Preprint]. 2024 Sep 19:2024.09.19.613696. doi: 10.1101/2024.09.19.613696. bioRxiv. 2024. PMID: 39345583 Free PMC article. Preprint.
Poly ADP-ribose signaling is dysregulated in Huntington disease.
Maiuri T, Bazan CB, Harding RJ, Begeja N, Kam TI, Byrne LM, Rodrigues FB, Warner MM, Neuman K, Mansoor M, Badiee M, Dasovich M, Wang K, Thompson LM, Leung AKL, Andres SN, Wild EJ, Dawson TM, Dawson VL, Arrowsmith CH, Truant R. Maiuri T, et al. Among authors: leung akl. Proc Natl Acad Sci U S A. 2024 Oct;121(40):e2318098121. doi: 10.1073/pnas.2318098121. Epub 2024 Sep 27. Proc Natl Acad Sci U S A. 2024. PMID: 39331414
A ligand discovery toolbox for the WWE domain family of human E3 ligases.
Münzker L, Kimani SW, Fowkes MM, Dong A, Zheng H, Li Y, Dasovich M, Zak KM, Leung AKL, Elkins JM, Kessler D, Arrowsmith CH, Halabelian L, Böttcher J. Münzker L, et al. Among authors: leung akl. Commun Biol. 2024 Jul 24;7(1):901. doi: 10.1038/s42003-024-06584-w. Commun Biol. 2024. PMID: 39048679 Free PMC article.
136 results