A novel pectin-like polysaccharide from Crocus sativus targets Galectin-3 to inhibit hepatic stellate cells activation and liver fibrosis.
Tang B, Jin C, Li M, Liu S, Zhang X, Li J, Ding K, Zang Y.
Tang B, et al.
Carbohydr Polym. 2025 Jan 15;348(Pt A):122826. doi: 10.1016/j.carbpol.2024.122826. Epub 2024 Oct 2.
Carbohydr Polym. 2025.
PMID: 39562101
O-3 branches include 1, 3-Gal, 1, 4-Gal, 1, 6-Gal, T-Gal, and T-Glc, while O-4 branches consist of 1, 2, 4-Rha, 1, 4-GalA, 1, 5-Ara, T-Ara, T-Gal, and T-alpha-HexA. Surface plasmon resonance measurement shows that XHH2 binds to both Gal-3 and integrin …
O-3 branches include 1, 3-Gal, 1, 4-Gal, 1, 6-Gal, T-Gal, and T-Glc, while O-4 branches consist of 1, 2, 4-Rha, 1, 4-GalA, 1, 5-Ara, …