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Page 1
Metabolic Syndrome Nonalcoholic Steatohepatitis Male Mouse With Adeno-Associated Viral Renin as a Novel Model for Heart Failure With Preserved Ejection Fraction.
Shi Y, Perez-Bonilla P, Chen X, Tam K, Marshall M, Morin J, LaViolette B, Kue NR, Damilano F, Miller RA, Zhang BB, Roth Flach RJ, Hirenallur-Shanthappa D. Shi Y, et al. Among authors: roth flach rj. J Am Heart Assoc. 2024 Dec 3;13(23):e035894. doi: 10.1161/JAHA.124.035894. Epub 2024 Nov 22. J Am Heart Assoc. 2024. PMID: 39575718 Free PMC article.
Discovery of First Branched-Chain Ketoacid Dehydrogenase Kinase (BDK) Inhibitor Clinical Candidate PF-07328948.
Filipski KJ, Martinez-Alsina LA, Reese MR, Evrard E, Buzon LM, Cameron KO, Zhang Y, Coffman KJ, Bradow J, Kormos BL, Liu S, Knafels JD, Sahasrabudhe PV, Chen J, Kalgutkar AS, Bessire AJ, Orozco CC, Balesano A, Cerny MA, Bollinger E, Reyes AR, Laforest B, Rosado A, Williams G, Marshall M, Tam Neale K, Chen X, Hirenallur-Shanthappa D, Stansfield JC, Groarke J, Qiu R, Karas S, Roth Flach RJ, Esler WP. Filipski KJ, et al. Among authors: roth flach rj. J Med Chem. 2024 Nov 19. doi: 10.1021/acs.jmedchem.4c02230. Online ahead of print. J Med Chem. 2024. PMID: 39560668
Two-hit mouse model of heart failure with preserved ejection fraction combining diet-induced obesity and renin-mediated hypertension.
Berger JH, Shi Y, Matsuura TR, Batmanov K, Chen X, Tam K, Marshall M, Kue R, Patel J, Taing R, Callaway R, Griffin J, Kovacs A, Shanthappa DH, Miller R, Zhang BB, Roth Flach RJ, Kelly DP. Berger JH, et al. Among authors: roth flach rj. bioRxiv [Preprint]. 2024 Jun 9:2024.06.06.597821. doi: 10.1101/2024.06.06.597821. bioRxiv. 2024. Update in: Sci Rep. 2025 Jan 2;15(1):422. doi: 10.1038/s41598-024-84515-9 PMID: 38895483 Free PMC article. Updated. Preprint.
Small molecule branched-chain ketoacid dehydrogenase kinase (BDK) inhibitors with opposing effects on BDK protein levels.
Roth Flach RJ, Bollinger E, Reyes AR, Laforest B, Kormos BL, Liu S, Reese MR, Martinez Alsina LA, Buzon L, Zhang Y, Bechle B, Rosado A, Sahasrabudhe PV, Knafels J, Bhattacharya SK, Omoto K, Stansfield JC, Hurley LD, Song L, Luo L, Breitkopf SB, Monetti M, Cunio T, Tierney B, Geoly FJ, Delmore J, Siddall CP, Xue L, Yip KN, Kalgutkar AS, Miller RA, Zhang BB, Filipski KJ. Roth Flach RJ, et al. Nat Commun. 2023 Aug 9;14(1):4812. doi: 10.1038/s41467-023-40536-y. Nat Commun. 2023. PMID: 37558654 Free PMC article.
Mixed meal tolerance testing highlights in diabetes altered branched-chain ketoacid metabolism and pathways associated with all-cause mortality.
Mi MY, Whitlock M, Shi X, Farrell LA, Bhambhani VM, Quadir J, Blatnik M, Wald KP, Tierney B, Kim A, Loudon P, Chen ZZ, Correa A, Gao Y, Carson AP, Bertoni AG, Roth Flach RJ, Gerszten RE. Mi MY, et al. Among authors: roth flach rj. Am J Clin Nutr. 2023 Mar;117(3):529-539. doi: 10.1016/j.ajcnut.2023.01.001. Epub 2023 Jan 7. Am J Clin Nutr. 2023. PMID: 36811472 Free PMC article.
Structural studies identify angiotensin II receptor blocker-like compounds as branched-chain ketoacid dehydrogenase kinase inhibitors.
Liu S, Kormos BL, Knafels JD, Sahasrabudhe PV, Rosado A, Sommese RF, Reyes AR, Ward J, Roth Flach RJ, Wang X, Buzon LM, Reese MR, Bhattacharya SK, Omoto K, Filipski KJ. Liu S, et al. Among authors: roth flach rj. J Biol Chem. 2023 Mar;299(3):102959. doi: 10.1016/j.jbc.2023.102959. Epub 2023 Jan 28. J Biol Chem. 2023. PMID: 36717078 Free PMC article.
BDK inhibition acts as a catabolic switch to mimic fasting and improve metabolism in mice.
Bollinger E, Peloquin M, Libera J, Albuquerque B, Pashos E, Shipstone A, Hadjipanayis A, Sun Z, Xing G, Clasquin M, Stansfield JC, Tierney B, Gernhardt S, Siddall CP, Greizer T, Geoly FJ, Vargas SR, Gao LC, Williams G, Marshall M, Rosado A, Steppan C, Filipski KJ, Zhang BB, Miller RA, Roth Flach RJ. Bollinger E, et al. Among authors: roth flach rj. Mol Metab. 2022 Dec;66:101611. doi: 10.1016/j.molmet.2022.101611. Epub 2022 Oct 8. Mol Metab. 2022. PMID: 36220546 Free PMC article.
An assessment of thermoneutral housing conditions on murine cardiometabolic function.
Chen X, Bollinger E, Cunio T, Damilano F, Stansfield JC, Pinkus CA, Kreuser S, Hirenallur-Shanthappa D, Roth Flach RJ. Chen X, et al. Among authors: roth flach rj. Am J Physiol Heart Circ Physiol. 2022 Feb 1;322(2):H234-H245. doi: 10.1152/ajpheart.00461.2021. Epub 2021 Dec 17. Am J Physiol Heart Circ Physiol. 2022. PMID: 34919456 Free article.
25 results