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Identification of TAK-756, A Potent TAK1 Inhibitor for the Treatment of Osteoarthritis through Intra-Articular Administration.
J Med Chem. 2024 Dec 12;67(23):21163-21185. doi: 10.1021/acs.jmedchem.4c01938. Epub 2024 Nov 22.
J Med Chem. 2024.
PMID: 39576936
Gene-signature-derived IC50s/EC50s reflect the potency of causative upstream targets and downstream phenotypes.
Renner S, Bergsdorf C, Bouhelal R, Koziczak-Holbro M, Amati AM, Techer-Etienne V, Flotte L, Reymann N, Kapur K, Hoersch S, Oakeley EJ, Schuffenhauer A, Gubler H, Lounkine E, Farmer P.
Renner S, et al. Among authors: flotte l.
Sci Rep. 2020 Jun 15;10(1):9670. doi: 10.1038/s41598-020-66533-5.
Sci Rep. 2020.
PMID: 32541899
Free PMC article.
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Pharmacological Characterization of a Novel 5-Hydroxybenzothiazolone-Derived β 2-Adrenoceptor Agonist with Functional Selectivity for Anabolic Effects on Skeletal Muscle Resulting in a Wider Cardiovascular Safety Window in Preclinical Studies.
Koziczak-Holbro M, Rigel DF, Dumotier B, Sykes DA, Tsao J, Nguyen NH, Bösch J, Jourdain M, Flotte L, Adachi Y, Kiffe M, Azria M, Fairhurst RA, Charlton SJ, Richardson BP, Lach-Trifilieff E, Glass DJ, Ullrich T, Hatakeyama S.
Koziczak-Holbro M, et al. Among authors: flotte l.
J Pharmacol Exp Ther. 2019 May;369(2):188-199. doi: 10.1124/jpet.118.255307. Epub 2019 Feb 28.
J Pharmacol Exp Ther. 2019.
PMID: 30819762
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