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Page 1
The TNF family member APRIL promotes colorectal tumorigenesis.
Lascano V, Zabalegui LF, Cameron K, Guadagnoli M, Jansen M, Burggraaf M, Versloot M, Rodermond H, van der Loos C, Carvalho-Pinto CE, Kalthoff H, Medema JP, Hahne M. Lascano V, et al. Among authors: medema jp. Cell Death Differ. 2012 Nov;19(11):1826-35. doi: 10.1038/cdd.2012.68. Epub 2012 Jun 15. Cell Death Differ. 2012. PMID: 22705846 Free PMC article.
Betulinic acid induces a novel cell death pathway that depends on cardiolipin modification.
Potze L, Di Franco S, Grandela C, Pras-Raves ML, Picavet DI, van Veen HA, van Lenthe H, Mullauer FB, van der Wel NN, Luyf A, van Kampen AH, Kemp S, Everts V, Kessler JH, Vaz FM, Medema JP. Potze L, et al. Among authors: medema jp. Oncogene. 2016 Jan 28;35(4):427-37. doi: 10.1038/onc.2015.102. Epub 2015 Apr 20. Oncogene. 2016. PMID: 25893306
Consensus molecular subtypes of colorectal cancer are recapitulated in in vitro and in vivo models.
Linnekamp JF, Hooff SRV, Prasetyanti PR, Kandimalla R, Buikhuisen JY, Fessler E, Ramesh P, Lee KAST, Bochove GGW, de Jong JH, Cameron K, Leersum RV, Rodermond HM, Franitza M, Nürnberg P, Mangiapane LR, Wang X, Clevers H, Vermeulen L, Stassi G, Medema JP. Linnekamp JF, et al. Among authors: medema jp. Cell Death Differ. 2018 Mar;25(3):616-633. doi: 10.1038/s41418-017-0011-5. Epub 2018 Jan 5. Cell Death Differ. 2018. PMID: 29305587 Free PMC article.
RNF43 truncations trap CK1 to drive niche-independent self-renewal in cancer.
Spit M, Fenderico N, Jordens I, Radaszkiewicz T, Lindeboom RG, Bugter JM, Cristobal A, Ootes L, van Osch M, Janssen E, Boonekamp KE, Hanakova K, Potesil D, Zdrahal Z, Boj SF, Medema JP, Bryja V, Koo BK, Vermeulen M, Maurice MM. Spit M, et al. Among authors: medema jp. EMBO J. 2020 Sep 15;39(18):e103932. doi: 10.15252/embj.2019103932. Epub 2020 Aug 10. EMBO J. 2020. PMID: 32965059 Free PMC article.
Driver mutations of the adenoma-carcinoma sequence govern the intestinal epithelial global translational capacity.
Smit WL, Spaan CN, Johannes de Boer R, Ramesh P, Martins Garcia T, Meijer BJ, Vermeulen JLM, Lezzerini M, MacInnes AW, Koster J, Medema JP, van den Brink GR, Muncan V, Heijmans J. Smit WL, et al. Among authors: medema jp. Proc Natl Acad Sci U S A. 2020 Oct 13;117(41):25560-25570. doi: 10.1073/pnas.1912772117. Epub 2020 Sep 28. Proc Natl Acad Sci U S A. 2020. PMID: 32989144 Free PMC article.
253 results