Strasser DS - Search Results

1

Cenerimod, a sphingosine-1-phosphate receptor modulator, versus placebo in patients with moderate-to-severe systemic lupus erythematosus (CARE): an international, double-blind, randomised, placebo-controlled, phase 2 trial.

Askanase AD, D'Cruz D, Kalunian K, Merrill JT, Navarra SV, Cahuzac C, Cornelisse P, Murphy MJ, Strasser DS, Trokan L, Berkani O. Askanase AD, et al. Among authors: strasser ds. Lancet Rheumatol. 2025 Jan;7(1):e21-e32. doi: 10.1016/S2665-9913(24)00246-7. Epub 2024 Nov 22. Lancet Rheumatol. 2025. PMID: 39586304 Clinical Trial.

2

Pharmacodynamics of the S1P₁ receptor modulator cenerimod in a phase 2b randomised clinical trial in patients with moderate to severe SLE.

Suffiotti M, Brazauskas P, Keller MP, Berkani O, Seifer G, Cornelisse P, Murphy MJ, Strasser DS. Suffiotti M, et al. Among authors: strasser ds. Ann Rheum Dis. 2024 Nov 24:ard-2024-226547. doi: 10.1136/ard-2024-226547. Online ahead of print. Ann Rheum Dis. 2024. PMID: 39581631 Free article.

3

Preclinical to clinical translation of cenerimod, a novel S1P₁ receptor modulator, in systemic lupus erythematosus.

Strasser DS, Froidevaux S, Sippel V, Gerossier E, Grieder U, Pierlot GM, Kieninger-Graefitsch A, Vezzali E, Stalder AK, Renault B, Ryge J, Hart A, Mentzel U, Groenen PMA, Keller MP, Trendelenburg M, Martinic MM, Murphy MJ. Strasser DS, et al. RMD Open. 2020 Sep;6(2):e001261. doi: 10.1136/rmdopen-2020-001261. RMD Open. 2020. PMID: 32917831 Free PMC article.

4

Discovery of Clinical Candidate ACT-777991, a Potent CXCR3 Antagonist for Antigen-Driven and Inflammatory Pathologies.

Meyer EA, Äänismaa P, Ertel EA, Hühn E, Strasser DS, Rey M, Murphy MJ, Martinic MM, Pouzol L, Froidevaux S, Keller MP, Caroff E. Meyer EA, et al. Among authors: strasser ds. J Med Chem. 2023 Mar 23;66(6):4179-4196. doi: 10.1021/acs.jmedchem.3c00074. Epub 2023 Mar 8. J Med Chem. 2023. PMID: 36883854

5

Attenuation of murine sclerodermatous models by the selective S1P₁ receptor modulator cenerimod.

Kano M, Kobayashi T, Date M, Tennichi M, Hamaguchi Y, Strasser DS, Takehara K, Matsushita T. Kano M, et al. Among authors: strasser ds. Sci Rep. 2019 Jan 24;9(1):658. doi: 10.1038/s41598-018-37074-9. Sci Rep. 2019. PMID: 30679645 Free PMC article.

6

A Multipurpose First-in-Human Study With the Novel CXCR7 Antagonist ACT-1004-1239 Using CXCL12 Plasma Concentrations as Target Engagement Biomarker.

Huynh C, Henrich A, Strasser DS, Boof ML, Al-Ibrahim M, Meyer Zu Schwabedissen HE, Dingemanse J, Ufer M. Huynh C, et al. Among authors: strasser ds. Clin Pharmacol Ther. 2021 Jun;109(6):1648-1659. doi: 10.1002/cpt.2154. Epub 2021 Feb 15. Clin Pharmacol Ther. 2021. PMID: 33406277

7

Pharmacokinetics, pharmacodynamics and safety of the novel C-X-C chemokine receptor 3 antagonist ACT-777991: Results from the first-in-human study in healthy adults.

Boof ML, Géhin M, Voors-Pette C, Hsin CH, Sippel V, Strasser DS, Dingemanse J. Boof ML, et al. Among authors: strasser ds. Br J Clin Pharmacol. 2024 Feb;90(2):588-599. doi: 10.1111/bcp.15914. Epub 2023 Nov 16. Br J Clin Pharmacol. 2024. PMID: 37752659 Clinical Trial.

8

A novel CRTH2 antagonist: Single- and multiple-dose tolerability, pharmacokinetics, and pharmacodynamics of ACT-453859 in healthy subjects.

Géhin M, Strasser DS, Zisowsky J, Farine H, Groenen PM, Dingemanse J, Sidharta PN. Géhin M, et al. Among authors: strasser ds. J Clin Pharmacol. 2015 Jul;55(7):787-97. doi: 10.1002/jcph.478. Epub 2015 Mar 30. J Clin Pharmacol. 2015. PMID: 25655470 Clinical Trial.

9

Pharmacokinetics, pharmacodynamics, tolerability and prediction of clinically effective dose of ACT-774312: A novel CRTH2 antagonist.

Géhin M, Lott D, Farine H, Issac M, Strasser D, Sidharta P, Dingemanse J. Géhin M, et al. Basic Clin Pharmacol Toxicol. 2019 Jun;124(6):711-721. doi: 10.1111/bcpt.13197. Epub 2019 Feb 11. Basic Clin Pharmacol Toxicol. 2019. PMID: 30589994 Free article. Clinical Trial.

10

CXCR7 Antagonism Reduces Acute Lung Injury Pathogenesis.

Pouzol L, Sassi A, Baumlin N, Tunis M, Strasser DS, Lehembre F, Martinic MM. Pouzol L, et al. Among authors: strasser ds. Front Pharmacol. 2021 Nov 5;12:748740. doi: 10.3389/fphar.2021.748740. eCollection 2021. Front Pharmacol. 2021. PMID: 34803691 Free PMC article.

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