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Structural insights into the mechanisms of urea permeation and distinct inhibition modes of urea transporters.
Huang SM, Huang ZZ, Liu L, Xiong MY, Zhang C, Cai BY, Wang MW, Cai K, Jia YL, Wang JL, Zhang MH, Xie YH, Li M, Zhang H, Weng CH, Wen X, Li Z, Sun Y, Yi F, Yang Z, Xiao P, Yang F, Yu X, Tie L, Yang BX, Sun JP. Huang SM, et al. Among authors: yu x. Nat Commun. 2024 Nov 26;15(1):10226. doi: 10.1038/s41467-024-54305-y. Nat Commun. 2024. PMID: 39587082 Free PMC article.
Structural basis of GPBAR activation and bile acid recognition.
Yang F, Mao C, Guo L, Lin J, Ming Q, Xiao P, Wu X, Shen Q, Guo S, Shen DD, Lu R, Zhang L, Huang S, Ping Y, Zhang C, Ma C, Zhang K, Liang X, Shen Y, Nan F, Yi F, Luca VC, Zhou J, Jiang C, Sun JP, Xie X, Yu X, Zhang Y. Yang F, et al. Among authors: yu x. Nature. 2020 Nov;587(7834):499-504. doi: 10.1038/s41586-020-2569-1. Epub 2020 Jul 22. Nature. 2020. PMID: 32698187
Structures of the glucocorticoid-bound adhesion receptor GPR97-Go complex.
Ping YQ, Mao C, Xiao P, Zhao RJ, Jiang Y, Yang Z, An WT, Shen DD, Yang F, Zhang H, Qu C, Shen Q, Tian C, Li ZJ, Li S, Wang GY, Tao X, Wen X, Zhong YN, Yang J, Yi F, Yu X, Xu HE, Zhang Y, Sun JP. Ping YQ, et al. Among authors: yu x. Nature. 2021 Jan;589(7843):620-626. doi: 10.1038/s41586-020-03083-w. Epub 2021 Jan 6. Nature. 2021. PMID: 33408414
Structure, function and pharmacology of human itch receptor complexes.
Yang F, Guo L, Li Y, Wang G, Wang J, Zhang C, Fang GX, Chen X, Liu L, Yan X, Liu Q, Qu C, Xu Y, Xiao P, Zhu Z, Li Z, Zhou J, Yu X, Gao N, Sun JP. Yang F, et al. Among authors: yu x. Nature. 2021 Dec;600(7887):164-169. doi: 10.1038/s41586-021-04077-y. Epub 2021 Nov 17. Nature. 2021. PMID: 34789875
Tethered peptide activation mechanism of the adhesion GPCRs ADGRG2 and ADGRG4.
Xiao P, Guo S, Wen X, He QT, Lin H, Huang SM, Gou L, Zhang C, Yang Z, Zhong YN, Yang CC, Li Y, Gong Z, Tao XN, Yang ZS, Lu Y, Li SL, He JY, Wang C, Zhang L, Kong L, Sun JP, Yu X. Xiao P, et al. Among authors: yu x. Nature. 2022 Apr;604(7907):771-778. doi: 10.1038/s41586-022-04590-8. Epub 2022 Apr 13. Nature. 2022. PMID: 35418677
Structure of GPR101-Gs enables identification of ligands with rejuvenating potential.
Yang Z, Wang JY, Yang F, Zhu KK, Wang GP, Guan Y, Ning SL, Lu Y, Li Y, Zhang C, Zheng Y, Zhou SH, Wang XW, Wang MW, Xiao P, Yi F, Zhang C, Zhang PJ, Xu F, Liu BH, Zhang H, Yu X, Gao N, Sun JP. Yang Z, et al. Among authors: yu x. Nat Chem Biol. 2024 Apr;20(4):484-492. doi: 10.1038/s41589-023-01456-6. Epub 2023 Nov 9. Nat Chem Biol. 2024. PMID: 37945893
Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling.
Liu CH, Gong Z, Liang ZL, Liu ZX, Yang F, Sun YJ, Ma ML, Wang YJ, Ji CR, Wang YH, Wang MJ, Cui FA, Lin A, Zheng WS, He DF, Qu CX, Xiao P, Liu CY, Thomsen AR, Joseph Cahill T 3rd, Kahsai AW, Yi F, Xiao KH, Xue T, Zhou Z, Yu X, Sun JP. Liu CH, et al. Among authors: yu x. Nat Commun. 2017 Feb 9;8:14335. doi: 10.1038/ncomms14335. Nat Commun. 2017. PMID: 28181498 Free PMC article.
Allosteric mechanisms underlie GPCR signaling to SH3-domain proteins through arrestin.
Yang F, Xiao P, Qu CX, Liu Q, Wang LY, Liu ZX, He QT, Liu C, Xu JY, Li RR, Li MJ, Li Q, Guo XZ, Yang ZY, He DF, Yi F, Ruan K, Shen YM, Yu X, Sun JP, Wang J. Yang F, et al. Among authors: yu x. Nat Chem Biol. 2018 Sep;14(9):876-886. doi: 10.1038/s41589-018-0115-3. Epub 2018 Aug 17. Nat Chem Biol. 2018. PMID: 30120361
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