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Rare variant associations with plasma protein levels in the UK Biobank.
Dhindsa RS, Burren OS, Sun BB, Prins BP, Matelska D, Wheeler E, Mitchell J, Oerton E, Hristova VA, Smith KR, Carss K, Wasilewski S, Harper AR, Paul DS, Fabre MA, Runz H, Viollet C, Challis B, Platt A; AstraZeneca Genomics Initiative; Vitsios D, Ashley EA, Whelan CD, Pangalos MN, Wang Q, Petrovski S. Dhindsa RS, et al. Nature. 2023 Oct;622(7982):339-347. doi: 10.1038/s41586-023-06547-x. Epub 2023 Oct 4. Nature. 2023. PMID: 37794183 Free PMC article.
Genetic architecture of telomere length in 462,666 UK Biobank whole-genome sequences.
Burren OS, Dhindsa RS, Deevi SVV, Wen S, Nag A, Mitchell J, Hu F, Loesch DP, Smith KR, Razdan N, Olsson H, Platt A, Vitsios D, Wu Q; AstraZeneca Genomics Initiative; Codd V, Nelson CP, Samani NJ, March RE, Wasilewski S, Carss K, Fabre M, Wang Q, Pangalos MN, Petrovski S. Burren OS, et al. Nat Genet. 2024 Sep;56(9):1832-1840. doi: 10.1038/s41588-024-01884-7. Epub 2024 Aug 27. Nat Genet. 2024. PMID: 39192095 Free PMC article.
Multiomics links global surfactant dysregulation with airflow obstruction and emphysema in COPD.
Hristova VA, Watson A, Chaerkady R, Glover MS, Ackland J, Angerman B, Belfield G, Belvisi MG, Burke H, Cellura D, Clark HW, Etal D, Freeman A, Heinson AI, Hess S, Hühn M, Hall E, Mackay A, Madsen J, McCrae C, Muthas D, Novick S, Ostridge K, Öberg L, Platt A, Postle AD, Spalluto CM, Vaarala O, Wang J, Staples KJ, Wilkinson TMA; MICA II Study group. Hristova VA, et al. Among authors: hess s. ERJ Open Res. 2022 May 15;9(3):00378-2022. doi: 10.1183/23120541.00378-2022. eCollection 2023 May. ERJ Open Res. 2022. PMID: 37228288 Free PMC article.
Sex-specific effects of CD248 on metabolism and the adipose tissue lipidome.
Patrick K, Tian X, Cartwright D, Heising S, Glover MS, Northall EN, Cazares L, Hess S, Baker D, Church C, Davies G, Lavery G, Naylor AJ. Patrick K, et al. Among authors: hess s. PLoS One. 2023 Apr 28;18(4):e0284012. doi: 10.1371/journal.pone.0284012. eCollection 2023. PLoS One. 2023. PMID: 37115796 Free PMC article.
A randomized phase 2b trial examined the effects of the glucagon-like peptide-1 and glucagon receptor agonist cotadutide on kidney outcomes in patients with diabetic kidney disease.
Selvarajah V, Robertson D, Hansen L, Jermutus L, Smith K, Coggi A, Sánchez J, Chang YT, Yu H, Parkinson J, Khan A, Chung HS, Hess S, Dumas R, Duck T, Jolly S, Elliott TG, Baker J, Lecube A, Derwahl KM, Scott R, Morales C, Peters C, Goldenberg R, Parker VER, Heerspink HJL; study investigators. Selvarajah V, et al. Among authors: hess s. Kidney Int. 2024 Dec;106(6):1170-1180. doi: 10.1016/j.kint.2024.08.023. Epub 2024 Aug 31. Kidney Int. 2024. PMID: 39218393 Free article. Clinical Trial.
Elevated Adipocyte Membrane Phospholipid Saturation Does Not Compromise Insulin Signaling.
Palmgren H, Petkevicius K, Bartesaghi S, Ahnmark A, Ruiz M, Nilsson R, Löfgren L, Glover MS, Andréasson AC, Andersson L, Becquart C, Kurczy M, Kull B, Wallin S, Karlsson D, Hess S, Maresca M, Bohlooly-Y M, Peng XR, Pilon M. Palmgren H, et al. Among authors: hess s. Diabetes. 2023 Oct 1;72(10):1350-1363. doi: 10.2337/db22-0293. Diabetes. 2023. PMID: 36580483 Free PMC article.
Identification and development of TRPM4 antagonists to counteract neuronal excitotoxicity.
Binkle-Ladisch L, Pironet A, Zaliani A, Alcouffe C, Mensching D, Haferkamp U, Willing A, Woo MS, Erdmann A, Jessen T, Hess SD, Gribbon P, Pless O, Vennekens R, Friese MA. Binkle-Ladisch L, et al. Among authors: hess sd. iScience. 2024 Nov 19;27(12):111425. doi: 10.1016/j.isci.2024.111425. eCollection 2024 Dec 20. iScience. 2024. PMID: 39687019 Free PMC article.
1,243 results