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Roflumilast and cognition enhancement: A translational perspective.
Prickaerts J, Kerckhoffs J, Possemis N, van Overveld W, Verbeek F, Grooters T, Sambeth A, Blokland A. Prickaerts J, et al. Biomed Pharmacother. 2024 Dec;181:117707. doi: 10.1016/j.biopha.2024.117707. Epub 2024 Nov 25. Biomed Pharmacother. 2024. PMID: 39591666 Free article. Review.
The PDE4 inhibitor roflumilast improves memory in rodents at non-emetic doses.
Vanmierlo T, Creemers P, Akkerman S, van Duinen M, Sambeth A, De Vry J, Uz T, Blokland A, Prickaerts J. Vanmierlo T, et al. Among authors: prickaerts j. Behav Brain Res. 2016 Apr 15;303:26-33. doi: 10.1016/j.bbr.2016.01.031. Epub 2016 Jan 18. Behav Brain Res. 2016. PMID: 26794595
A proof of concept phase II study with the PDE-4 inhibitor roflumilast in patients with mild cognitive impairment or mild Alzheimer's disease dementia (ROMEMA): study protocol of a double-blind, randomized, placebo-controlled, between-subjects trial.
Possemis N, Verhey F, Prickaerts J, Blokland A, Ramakers I. Possemis N, et al. Among authors: prickaerts j. Trials. 2024 Mar 4;25(1):162. doi: 10.1186/s13063-024-08001-3. Trials. 2024. PMID: 38438923 Free PMC article.
234 results