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Safety and pharmacokinetics of GB1211, an oral galectin-3 inhibitor: a single- and multiple-dose first-in-human study in healthy participants.
Aslanis V, Slack RJ, MacKinnon AC, McClinton C, Tantawi S, Gravelle L, Nilsson UJ, Leffler H, Brooks A, Khindri SK, Marshall RP, Pedersen A, Schambye H, Zetterberg F. Aslanis V, et al. Among authors: mackinnon ac. Cancer Chemother Pharmacol. 2023 Mar;91(3):267-280. doi: 10.1007/s00280-023-04513-y. Epub 2023 Mar 13. Cancer Chemother Pharmacol. 2023. PMID: 36914828 Free PMC article. Clinical Trial.
Resistance to anti-PD-1/anti-PD-L1: galectin-3 inhibition with GB1211 reverses galectin-3-induced blockade of pembrolizumab and atezolizumab binding to PD-1/PD-L1.
Mabbitt J, Holyer ID, Roper JA, Nilsson UJ, Zetterberg FR, Vuong L, Mackinnon AC, Pedersen A, Slack RJ. Mabbitt J, et al. Among authors: mackinnon ac. Front Immunol. 2023 Aug 28;14:1250559. doi: 10.3389/fimmu.2023.1250559. eCollection 2023. Front Immunol. 2023. PMID: 37701441 Free PMC article.
Galectin-3: therapeutic targeting in liver disease.
Mackinnon AC, Tonev D, Jacoby B, Pinzani M, Slack RJ. Mackinnon AC, et al. Expert Opin Ther Targets. 2023 Jul-Dec;27(9):779-791. doi: 10.1080/14728222.2023.2258280. Epub 2023 Sep 15. Expert Opin Ther Targets. 2023. PMID: 37705214 Review.
Defining the mechanism of galectin-3-mediated TGF-β1 activation and its role in lung fibrosis.
Calver JF, Parmar NR, Harris G, Lithgo RM, Stylianou P, Zetterberg FR, Gooptu B, Mackinnon AC, Carr SB, Borthwick LA, Scott DJ, Stewart ID, Slack RJ, Jenkins RG, John AE. Calver JF, et al. Among authors: mackinnon ac. J Biol Chem. 2024 Jun;300(6):107300. doi: 10.1016/j.jbc.2024.107300. Epub 2024 Apr 18. J Biol Chem. 2024. PMID: 38641066 Free PMC article.
Discovery of the Selective and Orally Available Galectin-1 Inhibitor GB1908 as a Potential Treatment for Lung Cancer.
Zetterberg FR, Peterson K, Nilsson UJ, Andréasson Dahlgren K, Diehl C, Holyer I, Håkansson M, Khabut A, Kahl-Knutson B, Leffler H, MacKinnon AC, Roper JA, Slack RJ, Zarrizi R, Pedersen A. Zetterberg FR, et al. Among authors: mackinnon ac. J Med Chem. 2024 Jun 13;67(11):9374-9388. doi: 10.1021/acs.jmedchem.4c00485. Epub 2024 May 28. J Med Chem. 2024. PMID: 38804039
147 results