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Systematic in vitro evolution in Plasmodium falciparum reveals key determinants of drug resistance.
Luth MR, Godinez-Macias KP, Chen D, Okombo J, Thathy V, Cheng X, Daggupati S, Davies H, Dhingra SK, Economy JM, Edgar RCS, Gomez-Lorenzo MG, Istvan ES, Jado JC, LaMonte GM, Melillo B, Mok S, Narwal SK, Ndiaye T, Ottilie S, Palomo Diaz S, Park H, Peña S, Rocamora F, Sakata-Kato T, Small-Saunders JL, Summers RL, Tumwebaze PK, Vanaerschot M, Xia G, Yeo T, You A, Gamo FJ, Goldberg DE, Lee MCS, McNamara CW, Ndiaye D, Rosenthal PJ, Schreiber SL, Serra G, De Siqueira-Neto JL, Skinner-Adams TS, Uhlemann AC, Kato N, Lukens AK, Wirth DF, Fidock DA, Winzeler EA. Luth MR, et al. Among authors: goldberg de. Science. 2024 Nov 29;386(6725):eadk9893. doi: 10.1126/science.adk9893. Epub 2024 Nov 29. Science. 2024. PMID: 39607932
Distal substrate interactions enhance plasmepsin activity.
Istvan ES, Goldberg DE. Istvan ES, et al. Among authors: goldberg de. J Biol Chem. 2005 Feb 25;280(8):6890-6. doi: 10.1074/jbc.M412086200. Epub 2004 Dec 1. J Biol Chem. 2005. PMID: 15574427 Free article.
Hemoglobin-degrading plasmepsin II is active as a monomer.
Liu J, Istvan ES, Goldberg DE. Liu J, et al. Among authors: goldberg de. J Biol Chem. 2006 Dec 15;281(50):38682-8. doi: 10.1074/jbc.M608535200. Epub 2006 Oct 13. J Biol Chem. 2006. PMID: 17040901 Free article.
Plasmodium food vacuole plasmepsins are activated by falcipains.
Drew ME, Banerjee R, Uffman EW, Gilbertson S, Rosenthal PJ, Goldberg DE. Drew ME, et al. Among authors: goldberg de. J Biol Chem. 2008 May 9;283(19):12870-6. doi: 10.1074/jbc.M708949200. Epub 2008 Feb 28. J Biol Chem. 2008. PMID: 18308731 Free PMC article.
276 results