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Safety and immunogenicity of the ChAdOx1-MVA-vectored conserved mosaic HIVconsvX candidate T-cell vaccines in HIV-CORE 005.2, an open-label, dose-escalation, first-in-human, phase 1 trial in adults living without HIV-1 in the UK.
Borthwick N, Fernandez N, Hayes PJ, Wee EG, Akis Yildirim BM, Baines A, Baker M, Byard N, Conway O, Glaze M, Jenkin D, Larkworthy C, Luciw M, Platt A, Poulton I, Thomas M, Quaddy J, Watson M, Crook A, Cicconi P, Hanke T. Borthwick N, et al. Among authors: hanke t. Lancet Microbe. 2024 Nov 26:100956. doi: 10.1016/j.lanmic.2024.100956. Online ahead of print. Lancet Microbe. 2024. PMID: 39612921 Free article.
Parallel Induction of CH505 B Cell Ontogeny-Guided Neutralizing Antibodies and tHIVconsvX Conserved Mosaic-Specific T Cells against HIV-1.
Wee EG, Moyo NA, Saunders KO, LaBranche C, Donati F, Capucci S, Parks R, Borthwick N, Hannoun Z, Montefiori DC, Haynes BF, Hanke T. Wee EG, et al. Among authors: hanke t. Mol Ther Methods Clin Dev. 2019 Jun 29;14:148-160. doi: 10.1016/j.omtm.2019.06.003. eCollection 2019 Sep 13. Mol Ther Methods Clin Dev. 2019. PMID: 31367651 Free PMC article.
A DNA/MVA-based candidate human immunodeficiency virus vaccine for Kenya induces multi-specific T cell responses in rhesus macaques.
Wee EG, Patel S, McMichael AJ, Hanke T. Wee EG, et al. Among authors: hanke t. J Gen Virol. 2002 Jan;83(Pt 1):75-80. doi: 10.1099/0022-1317-83-1-75. J Gen Virol. 2002. PMID: 11752703
The minimum requirement for candidate human immunodeficiency virus (HIV) vaccines to enter clinical evaluation in humans should be their demonstrable immunogenicity in non-human primates: induction of antibodies neutralizing primary HIV isolates or elicitation of broad T c …
The minimum requirement for candidate human immunodeficiency virus (HIV) vaccines to enter clinical evaluation in humans should be their dem …
Specificity of CD8+ T-Cell Responses Following Vaccination with Conserved Regions of HIV-1 in Nairobi, Kenya.
Mohamed YS, Borthwick NJ, Moyo N, Murakoshi H, Akahoshi T, Siliquini F, Hannoun Z, Crook A, Hayes P, Fast PE, Mutua G, Jaoko W, Silva-Arrieta S, Llano A, Brander C, Takiguchi M, Hanke T. Mohamed YS, et al. Among authors: hanke t. Vaccines (Basel). 2020 May 29;8(2):260. doi: 10.3390/vaccines8020260. Vaccines (Basel). 2020. PMID: 32485938 Free PMC article.
455 results