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Page 1
High-resolution profile of neoantigen-specific TCR activation links moderate stimulation to increased resilience of engineered TCR-T cells.
Füchsl F, Untch J, Kavaka V, Zuleger G, Braun S, Schwanzer A, Jarosch S, Vogelsang C, de Andrade Krätzig N, Gosmann D, Öllinger R, Giansanti P, Hiltensperger M, Rad R, Busch DH, Beltrán E, Bräunlein E, Krackhardt AM. Füchsl F, et al. Among authors: kavaka v. Nat Commun. 2024 Dec 3;15(1):10520. doi: 10.1038/s41467-024-53911-0. Nat Commun. 2024. PMID: 39627205 Free PMC article.
Twin study identifies early immunological and metabolic dysregulation of CD8+ T cells in multiple sclerosis.
Kavaka V, Mutschler L, de la Rosa Del Val C, Eglseer K, Gómez Martínez AM, Flierl-Hecht A, Ertl-Wagner B, Keeser D, Mortazavi M, Seelos K, Zimmermann H, Haas J, Wildemann B, Kümpfel T, Dornmair K, Korn T, Hohlfeld R, Kerschensteiner M, Gerdes LA, Beltrán E. Kavaka V, et al. Sci Immunol. 2024 Sep 27;9(99):eadj8094. doi: 10.1126/sciimmunol.adj8094. Epub 2024 Sep 27. Sci Immunol. 2024. PMID: 39331727
A genome-wide in vivo CRISPR screen identifies essential regulators of T cell migration to the CNS in a multiple sclerosis model.
Kendirli A, de la Rosa C, Lämmle KF, Eglseer K, Bauer IJ, Kavaka V, Winklmeier S, Zhuo L, Wichmann C, Gerdes LA, Kümpfel T, Dornmair K, Beltrán E, Kerschensteiner M, Kawakami N. Kendirli A, et al. Among authors: kavaka v. Nat Neurosci. 2023 Oct;26(10):1713-1725. doi: 10.1038/s41593-023-01432-2. Epub 2023 Sep 14. Nat Neurosci. 2023. PMID: 37709997 Free PMC article.
Single-cell transcriptomic atlas-guided development of CAR-T cells for the treatment of acute myeloid leukemia.
Gottschlich A, Thomas M, Grünmeier R, Lesch S, Rohrbacher L, Igl V, Briukhovetska D, Benmebarek MR, Vick B, Dede S, Müller K, Xu T, Dhoqina D, Märkl F, Robinson S, Sendelhofert A, Schulz H, Umut Ö, Kavaka V, Tsiverioti CA, Carlini E, Nandi S, Strzalkowski T, Lorenzini T, Stock S, Müller PJ, Dörr J, Seifert M, Cadilha BL, Brabenec R, Röder N, Rataj F, Nüesch M, Modemann F, Wellbrock J, Fiedler W, Kellner C, Beltrán E, Herold T, Paquet D, Jeremias I, von Baumgarten L, Endres S, Subklewe M, Marr C, Kobold S. Gottschlich A, et al. Among authors: kavaka v. Nat Biotechnol. 2023 Nov;41(11):1618-1632. doi: 10.1038/s41587-023-01684-0. Epub 2023 Mar 13. Nat Biotechnol. 2023. PMID: 36914885 Free PMC article.
Persistent virus-specific and clonally expanded antibody-secreting cells respond to induced self-antigen in the CNS.
Agrafiotis A, Dizerens R, Vincenti I, Wagner I, Kuhn R, Shlesinger D, Manero-Carranza M, Cotet TS, Hong KL, Page N, Fonta N, Shammas G, Mariotte A, Piccinno M, Kreutzfeldt M, Gruntz B, Ehling R, Genovese A, Pedrioli A, Dounas A, Franzenburg S, Tumani H, Kümpfel T, Kavaka V, Gerdes LA, Dornmair K, Beltrán E, Oxenius A, Reddy ST, Merkler D, Yermanos A. Agrafiotis A, et al. Among authors: kavaka v. Acta Neuropathol. 2023 Mar;145(3):335-355. doi: 10.1007/s00401-023-02537-5. Epub 2023 Jan 25. Acta Neuropathol. 2023. PMID: 36695896 Free PMC article.
Twin study reveals non-heritable immune perturbations in multiple sclerosis.
Ingelfinger F, Gerdes LA, Kavaka V, Krishnarajah S, Friebel E, Galli E, Zwicky P, Furrer R, Peukert C, Dutertre CA, Eglseer KM, Ginhoux F, Flierl-Hecht A, Kümpfel T, De Feo D, Schreiner B, Mundt S, Kerschensteiner M, Hohlfeld R, Beltrán E, Becher B. Ingelfinger F, et al. Among authors: kavaka v. Nature. 2022 Mar;603(7899):152-158. doi: 10.1038/s41586-022-04419-4. Epub 2022 Feb 16. Nature. 2022. PMID: 35173329 Free PMC article.