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Bioisosteric analogs of MDMA: Improving the pharmacological profile?
Alberto-Silva AS, Hemmer S, Bock HA, da Silva LA, Scott KR, Kastner N, Bhatt M, Niello M, Jäntsch K, Kudlacek O, Bossi E, Stockner T, Meyer MR, McCorvy JD, Brandt SD, Kavanagh P, Sitte HH. Alberto-Silva AS, et al. Among authors: kudlacek o. J Neurochem. 2024 Sep;168(9):2022-2042. doi: 10.1111/jnc.16149. Epub 2024 Jun 19. J Neurochem. 2024. PMID: 38898705
Bioisosteric analogs of MDMA with improved pharmacological profile.
Alberto-Silva AS, Hemmer S, Bock HA, Alves da Silva L, Scott KR, Kastner N, Bhatt M, Niello M, Jäntsch K, Kudlacek O, Bossi E, Stockner T, Meyer MR, McCorvy JD, Brandt SD, Kavanagh P, Sitte HH. Alberto-Silva AS, et al. Among authors: kudlacek o. bioRxiv [Preprint]. 2024 Apr 11:2024.04.08.588083. doi: 10.1101/2024.04.08.588083. bioRxiv. 2024. Update in: J Neurochem. 2024 Sep;168(9):2022-2042. doi: 10.1111/jnc.16149 PMID: 38645142 Free PMC article. Updated. Preprint.
Phosphatidylinositol 4,5-bisphosphate (PIP2) facilitates norepinephrine transporter dimerization and modulates substrate efflux.
Luethi D, Maier J, Rudin D, Szöllősi D, Angenoorth TJF, Stankovic S, Schittmayer M, Burger I, Yang JW, Jaentsch K, Holy M, Das AK, Brameshuber M, Camacho-Hernandez GA, Casiraghi A, Newman AH, Kudlacek O, Birner-Gruenberger R, Stockner T, Schütz GJ, Sitte HH. Luethi D, et al. Among authors: kudlacek o. Commun Biol. 2022 Nov 17;5(1):1259. doi: 10.1038/s42003-022-04210-1. Commun Biol. 2022. PMID: 36396757 Free PMC article.
Serotonin-releasing agents with reduced off-target effects.
Mayer FP, Niello M, Cintulova D, Sideromenos S, Maier J, Li Y, Bulling S, Kudlacek O, Schicker K, Iwamoto H, Deng F, Wan J, Holy M, Katamish R, Sandtner W, Li Y, Pollak DD, Blakely RD, Mihovilovic MD, Baumann MH, Sitte HH. Mayer FP, et al. Among authors: kudlacek o. Mol Psychiatry. 2023 Feb;28(2):722-732. doi: 10.1038/s41380-022-01843-w. Epub 2022 Nov 9. Mol Psychiatry. 2023. PMID: 36352123 Free PMC article.
Structural basis of organic cation transporter-3 inhibition.
Khanppnavar B, Maier J, Herborg F, Gradisch R, Lazzarin E, Luethi D, Yang JW, Qi C, Holy M, Jäntsch K, Kudlacek O, Schicker K, Werge T, Gether U, Stockner T, Korkhov VM, Sitte HH. Khanppnavar B, et al. Among authors: kudlacek o. Nat Commun. 2022 Nov 7;13(1):6714. doi: 10.1038/s41467-022-34284-8. Nat Commun. 2022. PMID: 36344565 Free PMC article.
52 results