Qianzhu H - Search Results

1

Rendering Proteins Fluorescent Inconspicuously: Genetically Encoded 4-Cyanotryptophan Conserves Their Structure and Enables the Detection of Ligand Binding Sites.

Qianzhu H, Abdelkader EH, Welegedara AP, Habel E, Paul N, Frkic RL, Jackson CJ, Huber T, Otting G. Qianzhu H, et al. Angew Chem Int Ed Engl. 2024 Dec 4:e202421000. doi: 10.1002/anie.202421000. Online ahead of print. Angew Chem Int Ed Engl. 2024. PMID: 39632265

2

Genetic Encoding of Fluoro-l-tryptophans for Site-Specific Detection of Conformational Heterogeneity in Proteins by NMR Spectroscopy.

Qianzhu H, Abdelkader EH, Otting G, Huber T. Qianzhu H, et al. J Am Chem Soc. 2024 May 15;146(19):13641-13650. doi: 10.1021/jacs.4c03743. Epub 2024 Apr 30. J Am Chem Soc. 2024. PMID: 38687675

3

Genetic Encoding of 7-Aza-l-tryptophan: Isoelectronic Substitution of a Single CH-Group in a Protein for a Nitrogen Atom for Site-Selective Isotope Labeling.

Abdelkader EH, Qianzhu H, Huber T, Otting G. Abdelkader EH, et al. Among authors: qianzhu h. ACS Sens. 2023 Nov 24;8(11):4402-4406. doi: 10.1021/acssensors.3c01904. Epub 2023 Oct 27. ACS Sens. 2023. PMID: 37890165

4

Probing Ligand Binding Sites on Large Proteins by Nuclear Magnetic Resonance Spectroscopy of Genetically Encoded Non-Canonical Amino Acids.

Ekanayake KB, Mahawaththa MC, Qianzhu H, Abdelkader EH, George J, Ullrich S, Murphy RB, Fry SE, Johansen-Leete J, Payne RJ, Nitsche C, Huber T, Otting G. Ekanayake KB, et al. Among authors: qianzhu h. J Med Chem. 2023 Apr 13;66(7):5289-5304. doi: 10.1021/acs.jmedchem.3c00222. Epub 2023 Mar 15. J Med Chem. 2023. PMID: 36920850

5

Genetic Encoding of Cyanopyridylalanine for In-Cell Protein Macrocyclization by the Nitrile-Aminothiol Click Reaction.

Abdelkader EH, Qianzhu H, George J, Frkic RL, Jackson CJ, Nitsche C, Otting G, Huber T. Abdelkader EH, et al. Among authors: qianzhu h. Angew Chem Int Ed Engl. 2022 Mar 21;61(13):e202114154. doi: 10.1002/anie.202114154. Epub 2022 Feb 11. Angew Chem Int Ed Engl. 2022. PMID: 35102680 Free PMC article.

6

Site-Specific Incorporation of 7-Fluoro-L-tryptophan into Proteins by Genetic Encoding to Monitor Ligand Binding by ¹⁹F NMR Spectroscopy.

Qianzhu H, Abdelkader EH, Herath ID, Otting G, Huber T. Qianzhu H, et al. ACS Sens. 2022 Jan 28;7(1):44-49. doi: 10.1021/acssensors.1c02467. Epub 2022 Jan 10. ACS Sens. 2022. PMID: 35005899

7

Through-Space Scalar ¹⁹F-¹⁹F Couplings between Fluorinated Noncanonical Amino Acids for the Detection of Specific Contacts in Proteins.

Orton HW, Qianzhu H, Abdelkader EH, Habel EI, Tan YJ, Frkic RL, Jackson CJ, Huber T, Otting G. Orton HW, et al. Among authors: qianzhu h. J Am Chem Soc. 2021 Nov 24;143(46):19587-19598. doi: 10.1021/jacs.1c10104. Epub 2021 Nov 15. J Am Chem Soc. 2021. PMID: 34780162

8

Genetic Encoding of N⁶-(((Trimethylsilyl)methoxy)carbonyl)-l-lysine for NMR Studies of Protein-Protein and Protein-Ligand Interactions.

Abdelkader EH, Qianzhu H, Tan YJ, Adams LA, Huber T, Otting G. Abdelkader EH, et al. Among authors: qianzhu h. J Am Chem Soc. 2021 Jan 20;143(2):1133-1143. doi: 10.1021/jacs.0c11971. Epub 2021 Jan 5. J Am Chem Soc. 2021. PMID: 33399460

9

Genetic Encoding of para-Pentafluorosulfanyl Phenylalanine: A Highly Hydrophobic and Strongly Electronegative Group for Stable Protein Interactions.

Qianzhu H, Welegedara AP, Williamson H, McGrath AE, Mahawaththa MC, Dixon NE, Otting G, Huber T. Qianzhu H, et al. J Am Chem Soc. 2020 Oct 14;142(41):17277-17281. doi: 10.1021/jacs.0c07976. Epub 2020 Sep 30. J Am Chem Soc. 2020. PMID: 32975937

10

Nucleoside-linked shunt products in the reaction catalyzed by the class C radical S-adenosylmethionine methyltransferase NosN.

Ding W, Wu Y, Ji X, Qianzhu H, Chen F, Deng Z, Yu Y, Zhang Q. Ding W, et al. Among authors: qianzhu h. Chem Commun (Camb). 2017 May 4;53(37):5235-5238. doi: 10.1039/c7cc02162c. Chem Commun (Camb). 2017. PMID: 28443932

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