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High-prediction QSAR Modeling Study Based on the Efficacy of a Novel 6-hydroxybenzothiazole-2-carboxamide Targeted Monoamine Oxidase B in the Treatment of Neurodegenerative Diseases.
Xie D, Cai Z, Mao J, Qu X, Cao L, Zhou J. Xie D, et al. Med Chem. 2025 Jan 20. doi: 10.2174/0115734064364749250102024805. Online ahead of print. Med Chem. 2025. PMID: 39838656
These diseases are closely associated with increased expression of monoamine oxidase B (MAO-B), an important enzyme that regulates neurotransmitter concentration, and its overactivity leads to oxidative stress and neurotoxicity, accelerating the progre …
These diseases are closely associated with increased expression of monoamine oxidase B (MAO-B), an important enz …
Dual inhibition of AChE and MAO-B in Alzheimer's disease: machine learning approaches and model interpretations.
Hou Q, Li Y. Hou Q, et al. Mol Divers. 2025 Jan 21. doi: 10.1007/s11030-024-11061-x. Online ahead of print. Mol Divers. 2025. PMID: 39838228
Given the multifactorial pathophysiology of AD, monotargeted agents can only alleviate symptoms but not cure AD. Acetylcholinesterase (AChE) and Monoamine oxidase B (MAO-B) are two key targets in the treatment of AD, molecules that inhibiting both targ …
Given the multifactorial pathophysiology of AD, monotargeted agents can only alleviate symptoms but not cure AD. Acetylcholinesterase (AChE) …
MAO-B-triggered reaction for an optical triple-signal assay and AND logic gate application based on PEI-functionalized silver nanoparticles.
Zhang XR, Chai T, Chang XL, Zhang Y, Wang CB, Liu S, Iradukunda Y, Shang XY, Cao YH, Wang WF, Yang JL, Qiang Y. Zhang XR, et al. Mikrochim Acta. 2025 Jan 21;192(2):99. doi: 10.1007/s00604-024-06908-x. Mikrochim Acta. 2025. PMID: 39836294
A novel analytical method was designed and developed that exhibited ultraviolet-visible (UV-Vis), fluorescence (FL), and resonance Rayleigh scattering (RRS) signals for straightforward and comprehensive determination of monoamine oxidase B (MAO-B) usin …
A novel analytical method was designed and developed that exhibited ultraviolet-visible (UV-Vis), fluorescence (FL), and resonance Rayleigh …
Aging and MPTP Sensitivity Depend on Molecular and Ultrastructural Signatures of Astroglia and Microglia in Mice Substantia Nigra.
Abhilash PL, Bharti U, Rashmi SK, Philip M, Raju TR, Kutty BM, Sagar BKC, Alladi PA. Abhilash PL, et al. Cell Mol Neurobiol. 2025 Jan 20;45(1):13. doi: 10.1007/s10571-024-01528-8. Cell Mol Neurobiol. 2025. PMID: 39833644
MPTP challenge caused upregulation of enzymes MAO-A, MAO-B, and iNOS in both strains. Post-MPTP enhancement in fractalkine and hemeoxygenase-1 may be neuron-associated compensatory signals. ...
MPTP challenge caused upregulation of enzymes MAO-A, MAO-B, and iNOS in both strains. Post-MPTP enhancement in fractalkine and …
Exploring DMT: Endogenous Role and Therapeutic Potential.
Schimmelpfennig J, Jankowiak-Siuda K. Schimmelpfennig J, et al. Neuropharmacology. 2025 Jan 18:110314. doi: 10.1016/j.neuropharm.2025.110314. Online ahead of print. Neuropharmacology. 2025. PMID: 39832530 Review.
This review considers the impact of endogenous regulatory factors on DMT synthesis and degradation, particularly under conditions affecting monoamine oxidase (MAO) efficiency and activity. We also examined DMT's potential roles in various physiological processes, in …
This review considers the impact of endogenous regulatory factors on DMT synthesis and degradation, particularly under conditions affecting …
27,436 results
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