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Protease-activated receptors in health and disease.
Peach CJ, Edgington-Mitchell LE, Bunnett NW, Schmidt BL. Peach CJ, et al. Among authors: bunnett nw. Physiol Rev. 2023 Jan 1;103(1):717-785. doi: 10.1152/physrev.00044.2021. Epub 2022 Jul 28. Physiol Rev. 2023. PMID: 35901239 Free PMC article. Review.
Therapeutic antagonism of the neurokinin 1 receptor in endosomes provides sustained pain relief.
Hegron A, Peach CJ, Tonello R, Seemann P, Teng S, Latorre R, Huebner H, Weikert D, Rientjes J, Veldhuis NA, Poole DP, Jensen DD, Thomsen ARB, Schmidt BL, Imlach WL, Gmeiner P, Bunnett NW. Hegron A, et al. Among authors: bunnett nw. Proc Natl Acad Sci U S A. 2023 May 30;120(22):e2220979120. doi: 10.1073/pnas.2220979120. Epub 2023 May 22. Proc Natl Acad Sci U S A. 2023. PMID: 37216510 Free PMC article.
Mice expressing fluorescent PAR2 reveal that endocytosis mediates colonic inflammation and pain.
Latorre R, Hegron A, Peach CJ, Teng S, Tonello R, Retamal JS, Klein-Cloud R, Bok D, Jensen DD, Gottesman-Katz L, Rientjes J, Veldhuis NA, Poole DP, Schmidt BL, Pothoulakis CH, Rankin C, Xie Y, Koon HW, Bunnett NW. Latorre R, et al. Among authors: bunnett nw. Proc Natl Acad Sci U S A. 2022 Feb 8;119(6):e2112059119. doi: 10.1073/pnas.2112059119. Proc Natl Acad Sci U S A. 2022. PMID: 35110404 Free PMC article.
Neuropilin-1 is a co-receptor for Nerve Growth Factor-evoked pain.
Peach CJ, Tonello R, Damo E, Gomez K, Calderon-Rivera A, Bruni R, Bansia H, Maile L, Manu AM, Hahn H, Thomsen ARB, Schmidt BL, Davidson S, des Georges A, Khanna R, Bunnett NW. Peach CJ, et al. Among authors: bunnett nw. bioRxiv [Preprint]. 2024 Oct 21:2023.12.06.570398. doi: 10.1101/2023.12.06.570398. bioRxiv. 2024. PMID: 38106002 Free PMC article. Preprint.
Schwann cell endosome CGRP signals elicit periorbital mechanical allodynia in mice.
De Logu F, Nassini R, Hegron A, Landini L, Jensen DD, Latorre R, Ding J, Marini M, Souza Monteiro de Araujo D, Ramírez-Garcia P, Whittaker M, Retamal J, Titiz M, Innocenti A, Davis TP, Veldhuis N, Schmidt BL, Bunnett NW, Geppetti P. De Logu F, et al. Among authors: bunnett nw. Nat Commun. 2022 Feb 3;13(1):646. doi: 10.1038/s41467-022-28204-z. Nat Commun. 2022. PMID: 35115501 Free PMC article.
315 results