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Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries.
Gharahkhani P, Jorgenson E, Hysi P, Khawaja AP, Pendergrass S, Han X, Ong JS, Hewitt AW, Segrè AV, Rouhana JM, Hamel AR, Igo RP Jr, Choquet H, Qassim A, Josyula NS, Cooke Bailey JN, Bonnemaijer PWM, Iglesias A, Siggs OM, Young TL, Vitart V, Thiadens AAHJ, Karjalainen J, Uebe S, Melles RB, Nair KS, Luben R, Simcoe M, Amersinghe N, Cree AJ, Hohn R, Poplawski A, Chen LJ, Rong SS, Aung T, Vithana EN; NEIGHBORHOOD consortium; ANZRAG consortium; Biobank Japan project; FinnGen study; UK Biobank Eye and Vision Consortium; GIGA study group; 23 and Me Research Team; Tamiya G, Shiga Y, Yamamoto M, Nakazawa T, Currant H, Birney E, Wang X, Auton A, Lupton MK, Martin NG, Ashaye A, Olawoye O, Williams SE, Akafo S, Ramsay M, Hashimoto K, Kamatani Y, Akiyama M, Momozawa Y, Foster PJ, Khaw PT, Morgan JE, Strouthidis NG, Kraft P, Kang JH, Pang CP, Pasutto F, Mitchell P, Lotery AJ, Palotie A, van Duijn C, Haines JL, Hammond C, Pasquale LR, Klaver CCW, Hauser M, Khor CC, Mackey DA, Kubo M, Cheng CY, Craig JE, MacGregor S, Wiggs JL. Gharahkhani P, et al. Among authors: nair ks. Nat Commun. 2021 Feb 24;12(1):1258. doi: 10.1038/s41467-020-20851-4. Nat Commun. 2021. PMID: 33627673 Free PMC article.
GLIS1 regulates trabecular meshwork function and intraocular pressure and is associated with glaucoma in humans.
Nair KS, Srivastava C, Brown RV, Koli S, Choquet H, Kang HS, Kuo YM, Grimm SA, Sutherland C, Badea A, Johnson GA, Zhao Y, Yin J, Okamoto K, Clark G, Borrás T, Zode G, Kizhatil K, Chakrabarti S, John SWM, Jorgenson E, Jetten AM. Nair KS, et al. Nat Commun. 2021 Aug 12;12(1):4877. doi: 10.1038/s41467-021-25181-7. Nat Commun. 2021. PMID: 34385434 Free PMC article.
A multiethnic genome-wide analysis of 19,420 individuals identifies novel loci associated with axial length and shared genetic influences with refractive error and myopia.
Jiang C, Melles RB, Yin J, Fan Q, Guo X, Cheng CY, He M, Mackey DA, Guggenheim JA, Klaver C; Consortium for Refractive Error and Myopia (CREAM); Nair KS, Jorgenson E, Choquet H. Jiang C, et al. Among authors: nair ks. Front Genet. 2023 Jun 7;14:1113058. doi: 10.3389/fgene.2023.1113058. eCollection 2023. Front Genet. 2023. PMID: 37351342 Free PMC article.
Consensus Recommendations for Studies of Outflow Facility and Intraocular Pressure Regulation Using Ex Vivo Perfusion Approaches.
Acott TS, Fautsch MP, Mao W, Ethier CR, Huang AS, Kelley MJ, Aga M, Bhattacharya SK, Borras T, Bovenkamp D, Chowdhury UR, Clark AF, Dibas MI, Du Y, Elliott MH, Faralli JA, Gong H, Herberg S, Johnstone MA, Kaufman PL, Keller KE, Kelly RA, Krizaj D, Kuehn MH, Li HL, Lieberman R, Lin SC, Liu Y, McDonnell FS, McDowell CM, McLellan GJ, Mzyk P, Nair KS, Overby DR, Peters DM, Raghunathan V, Rao PV, Roddy GW, Sharif NA, Shim MS, Sun Y, Thomson BR, Toris CB, Willoughby CE, Zhang HF, Freddo TF, Fuchshofer R, Hill KR, Karimi A, Kizhatil K, Kopcyznski CC, Liton P, Patel G, Peng M, Pattabiraman PP, Prasanna G, Reina-Torres E, Samples EG, Samples JR, Steel CL, Strohmaier CA, Subramanian P, Sugali CK, van Batenburg-Sherwood J, Wong C, Youngblood H, Zode GS, White E, Stamer WD. Acott TS, et al. Among authors: nair ks. Invest Ophthalmol Vis Sci. 2024 Dec 2;65(14):32. doi: 10.1167/iovs.65.14.32. Invest Ophthalmol Vis Sci. 2024. PMID: 39693082 Free PMC article.
398 results