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Effects of COVID-19 virus-like particles on the behavioral and cognitive performance of human apolipoprotein E targeted replacement mice.
O'Niel A, Pederson A, Saltontall E, Nguyen K, Pantoja M, Chaudhari M, Sandholm P, Yoon E, Harrison HF, Boutros S, Hirsch AJ, Raber J. O'Niel A, et al. Among authors: hirsch aj. Front Immunol. 2024 Nov 26;15:1473366. doi: 10.3389/fimmu.2024.1473366. eCollection 2024. Front Immunol. 2024. PMID: 39660133 Free PMC article.
4-Substituted-2-Thiazole Amides as Viral Replication Inhibitors of Alphaviruses.
Garzan A, Ahmed SK, Haese NN, Sulgey G, Medica S, Smith JL, Zhang S, Ahmad F, Karyakarte S, Rasmussen L, DeFilippis V, Tekwani B, Bostwick R, Suto MJ, Hirsch AJ, Morrison TE, Heise MT, Augelli-Szafran CE, Streblow DN, Pathak AK, Moukha-Chafiq O. Garzan A, et al. Among authors: hirsch aj. J Med Chem. 2024 Dec 12;67(23):20858-20878. doi: 10.1021/acs.jmedchem.4c01073. Epub 2024 Dec 2. J Med Chem. 2024. PMID: 39621435
Aerosol delivery of SARS-CoV-2 human monoclonal antibodies in macaques limits viral replication and lung pathology.
Streblow DN, Hirsch AJ, Stanton JJ, Lewis AD, Colgin L, Hessell AJ, Kreklywich CN, Smith JL, Sutton WF, Chauvin D, Woo J, Bimber BN, LeBlanc CN, Acharya SN, O'Roak BJ, Sardar H, Sajadi MM, Tehrani ZR, Walter MR, Martinez-Sobrido L, Kobie JJ, Reader RJ, Olstad KJ, Hobbs TR, Saphire EO, Schendel SL, Carnahan RH, Knoch J, Branco LM, Crowe JE Jr, Van Rompay KKA, Lovalenti P, Vu Truong, Forthal DN, Haigwood NL. Streblow DN, et al. Among authors: hirsch aj. Nat Commun. 2023 Nov 3;14(1):7062. doi: 10.1038/s41467-023-42440-x. Nat Commun. 2023. PMID: 37923717 Free PMC article.
Blood-brain barrier penetration of non-replicating SARS-CoV-2 and S1 variants of concern induce neuroinflammation which is accentuated in a mouse model of Alzheimer's disease.
Erickson MA, Logsdon AF, Rhea EM, Hansen KM, Holden SJ, Banks WA, Smith JL, German C, Farr SA, Morley JE, Weaver RR, Hirsch AJ, Kovac A, Kontsekova E, Baumann KK, Omer MA, Raber J. Erickson MA, et al. Among authors: hirsch aj. Brain Behav Immun. 2023 Mar;109:251-268. doi: 10.1016/j.bbi.2023.01.010. Epub 2023 Jan 20. Brain Behav Immun. 2023. PMID: 36682515 Free PMC article.
Targeting Chikungunya Virus Replication by Benzoannulene Inhibitors.
Ahmed SK, Haese NN, Cowan JT, Pathak V, Moukha-Chafiq O, Smith VJ, Rodzinak KJ, Ahmad F, Zhang S, Bonin KM, Streblow AD, Streblow CE, Kreklywich CN, Morrison C, Sarkar S, Moorman N, Sander W, Allen R, DeFilippis V, Tekwani BL, Wu M, Hirsch AJ, Smith JL, Tower NA, Rasmussen L, Bostwick R, Maddry JA, Ananthan S, Gerdes JM, Augelli-Szafran CE, Suto MJ, Morrison TE, Heise MT, Streblow DN, Pathak AK. Ahmed SK, et al. Among authors: hirsch aj. J Med Chem. 2021 Apr 22;64(8):4762-4786. doi: 10.1021/acs.jmedchem.0c02183. Epub 2021 Apr 9. J Med Chem. 2021. PMID: 33835811 Free PMC article.
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