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Preclinical and Clinical Pharmacokinetics of JNJ-75220795, an siRNA Therapeutic Targeting PNPLA3, for Metabolic Dysfunction-Associated Steatohepatitis.
Jeon JY, Ayyar VS, Ouchi S, Fabbrini E, Koshkina A, Prusakiewicz JJ, Dallas J, Yang T, Jian W, Kang L, Cofsky K, Rady B, Tamamura R, Saito Y, Yamashita A, Vaughan T, Wendel S, Makimura H, Csonka D, Goyal N. Jeon JY, et al. Among authors: kang l. J Clin Pharmacol. 2024 Dec 9. doi: 10.1002/jcph.6174. Online ahead of print. J Clin Pharmacol. 2024. PMID: 39654352
LC-MS bioanalysis of intact proteins and peptides.
Kang L, Weng N, Jian W. Kang L, et al. Biomed Chromatogr. 2020 Jan;34(1):e4633. doi: 10.1002/bmc.4633. Epub 2019 Aug 13. Biomed Chromatogr. 2020. PMID: 31257628 Review.
A Long-Acting PYY3-36 Analog Mediates Robust Anorectic Efficacy with Minimal Emesis in Nonhuman Primates.
Rangwala SM, D'Aquino K, Zhang YM, Bader L, Edwards W, Zheng S, Eckardt A, Lacombe A, Pick R, Moreno V, Kang L, Jian W, Arnoult E, Case M, Jenkinson C, Chi E, Swanson RV, Kievit P, Grove K, Macielag M, Erion MD, SinhaRoy R, Leonard JN. Rangwala SM, et al. Among authors: kang l. Cell Metab. 2019 Apr 2;29(4):837-843.e5. doi: 10.1016/j.cmet.2019.01.017. Epub 2019 Feb 14. Cell Metab. 2019. PMID: 30773465 Free PMC article.
Conjugation of a peptide to an antibody engineered with free cysteines dramatically improves half-life and activity.
Camacho RC, You S, D'Aquino KE, Li W, Wang Y, Gunnet J, Littrell J, Qi JS, Kang L, Jian W, MacDonald M, Tat T, Steiner D, Zhang YM, Lanter J, Patch R, Zhang R, Li J, Edavettal S, Edwards W, Dinh T, Wang LY, Connor J, Hunter M, Chi E, Swanson RV, Leonard JN, Case MA. Camacho RC, et al. Among authors: kang l. MAbs. 2020 Jan-Dec;12(1):1794687. doi: 10.1080/19420862.2020.1794687. MAbs. 2020. PMID: 32744157 Free PMC article.
4,621 results