Ninagawa S - Search Results

1

UGGT1-mediated reglucosylation of N-glycan competes with ER-associated degradation of unstable and misfolded glycoproteins.

Ninagawa S, Matsuo M, Ying D, Oshita S, Aso S, Matsushita K, Taniguchi M, Fueki A, Yamashiro M, Sugasawa K, Saito S, Imami K, Kizuka Y, Sakuma T, Yamamoto T, Yagi H, Kato K, Mori K. Ninagawa S, et al. Elife. 2024 Dec 10;12:RP93117. doi: 10.7554/eLife.93117. Elife. 2024. PMID: 39654396 Free PMC article.

2

EDEM2 stably disulfide-bonded to TXNDC11 catalyzes the first mannose trimming step in mammalian glycoprotein ERAD.

George G, Ninagawa S, Yagi H, Saito T, Ishikawa T, Sakuma T, Yamamoto T, Imami K, Ishihama Y, Kato K, Okada T, Mori K. George G, et al. Among authors: ninagawa s. Elife. 2020 Feb 17;9:e53455. doi: 10.7554/eLife.53455. Elife. 2020. PMID: 32065582 Free PMC article.

3

Purified EDEM3 or EDEM1 alone produces determinant oligosaccharide structures from M8B in mammalian glycoprotein ERAD.

George G, Ninagawa S, Yagi H, Furukawa JI, Hashii N, Ishii-Watabe A, Deng Y, Matsushita K, Ishikawa T, Mamahit YP, Maki Y, Kajihara Y, Kato K, Okada T, Mori K. George G, et al. Among authors: ninagawa s. Elife. 2021 Oct 26;10:e70357. doi: 10.7554/eLife.70357. Elife. 2021. PMID: 34698634 Free PMC article.

4

A motor neuron disease-associated mutation produces non-glycosylated Seipin that induces ER stress and apoptosis by inactivating SERCA2b.

Saito S, Ishikawa T, Ninagawa S, Okada T, Mori K. Saito S, et al. Among authors: ninagawa s. Elife. 2022 Nov 29;11:e74805. doi: 10.7554/eLife.74805. Elife. 2022. PMID: 36444643 Free PMC article.

5

SEL1L is required for endoplasmic reticulum-associated degradation of misfolded luminal proteins but not transmembrane proteins in chicken DT40 cell line.

Ninagawa S, Okada T, Takeda S, Mori K. Ninagawa S, et al. Cell Struct Funct. 2011;36(2):187-95. doi: 10.1247/csf.11018. Epub 2011 Aug 20. Cell Struct Funct. 2011. PMID: 21857145 Free article.

6

The unfolded protein response transducer ATF6 represents a novel transmembrane-type endoplasmic reticulum-associated degradation substrate requiring both mannose trimming and SEL1L protein.

Horimoto S, Ninagawa S, Okada T, Koba H, Sugimoto T, Kamiya Y, Kato K, Takeda S, Mori K. Horimoto S, et al. Among authors: ninagawa s. J Biol Chem. 2013 Nov 1;288(44):31517-27. doi: 10.1074/jbc.M113.476010. Epub 2013 Sep 16. J Biol Chem. 2013. PMID: 24043630 Free PMC article.

7

EDEM2 initiates mammalian glycoprotein ERAD by catalyzing the first mannose trimming step.

Ninagawa S, Okada T, Sumitomo Y, Kamiya Y, Kato K, Horimoto S, Ishikawa T, Takeda S, Sakuma T, Yamamoto T, Mori K. Ninagawa S, et al. J Cell Biol. 2014 Aug 4;206(3):347-56. doi: 10.1083/jcb.201404075. J Cell Biol. 2014. PMID: 25092655 Free PMC article.

8

Forcible destruction of severely misfolded mammalian glycoproteins by the non-glycoprotein ERAD pathway.

Ninagawa S, Okada T, Sumitomo Y, Horimoto S, Sugimoto T, Ishikawa T, Takeda S, Yamamoto T, Suzuki T, Kamiya Y, Kato K, Mori K. Ninagawa S, et al. J Cell Biol. 2015 Nov 23;211(4):775-84. doi: 10.1083/jcb.201504109. Epub 2015 Nov 16. J Cell Biol. 2015. PMID: 26572623 Free PMC article.

9

Reinvestigation of Disulfide-bonded Oligomeric Forms of the Unfolded Protein Response Transducer ATF6.

Koba H, Jin S, Imada N, Ishikawa T, Ninagawa S, Okada T, Sakuma T, Yamamoto T, Mori K. Koba H, et al. Among authors: ninagawa s. Cell Struct Funct. 2020 Jan 30;45(1):9-21. doi: 10.1247/csf.19030. Epub 2019 Dec 19. Cell Struct Funct. 2020. PMID: 31852864 Free PMC article.

10

Antipsychotic olanzapine-induced misfolding of proinsulin in the endoplasmic reticulum accounts for atypical development of diabetes.

Ninagawa S, Tada S, Okumura M, Inoguchi K, Kinoshita M, Kanemura S, Imami K, Umezawa H, Ishikawa T, Mackin RB, Torii S, Ishihama Y, Inaba K, Anazawa T, Nagamine T, Mori K. Ninagawa S, et al. Elife. 2020 Nov 17;9:e60970. doi: 10.7554/eLife.60970. Elife. 2020. PMID: 33198886 Free PMC article.

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