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Microbial-derived bile acid reverses inflammation in IBD via GPBAR1 agonism and RORγt inverse agonism.
Biagioli M, Di Giorgio C, Massa C, Marchianò S, Bellini R, Bordoni M, Urbani G, Roselli R, Lachi G, Morretta E, Piaz FD, Charlier B, Fiorillo B, Catalanotti B, Cari L, Nocentini G, Ricci P, Distrutti E, Festa C, Sepe V, Zampella A, Monti MC, Fiorucci S. Biagioli M, et al. Among authors: di giorgio c. Biomed Pharmacother. 2024 Dec;181:117731. doi: 10.1016/j.biopha.2024.117731. Epub 2024 Dec 9. Biomed Pharmacother. 2024. PMID: 39657506 Free article.
GPBAR1 Functions as Gatekeeper for Liver NKT Cells and provides Counterregulatory Signals in Mouse Models of Immune-Mediated Hepatitis.
Biagioli M, Carino A, Fiorucci C, Marchianò S, Di Giorgio C, Roselli R, Magro M, Distrutti E, Bereshchenko O, Scarpelli P, Zampella A, Fiorucci S. Biagioli M, et al. Among authors: di giorgio c. Cell Mol Gastroenterol Hepatol. 2019;8(3):447-473. doi: 10.1016/j.jcmgh.2019.06.003. Epub 2019 Jun 18. Cell Mol Gastroenterol Hepatol. 2019. PMID: 31226434 Free PMC article.
Opposite effects of the FXR agonist obeticholic acid on Mafg and Nrf2 mediate the development of acute liver injury in rodent models of cholestasis.
Carino A, Biagioli M, Marchianò S, Fiorucci C, Bordoni M, Roselli R, Di Giorgio C, Baldoni M, Ricci P, Monti MC, Morretta E, Zampella A, Distrutti E, Fiorucci S. Carino A, et al. Among authors: di giorgio c. Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Sep;1865(9):158733. doi: 10.1016/j.bbalip.2020.158733. Epub 2020 May 1. Biochim Biophys Acta Mol Cell Biol Lipids. 2020. PMID: 32371093
204 results