The immunoregulatory effects of CD8 T-cell-derived perforin on diet-induced nonalcoholic steatohepatitis.
Wang T, Sun G, Wang Y, Li S, Zhao X, Zhang C, Jin H, Tian D, Liu K, Shi W, Tian Y, Zhang D.
Wang T, et al. Among authors: sun g.
FASEB J. 2019 Jul;33(7):8490-8503. doi: 10.1096/fj.201802534RR. Epub 2019 Apr 5.
FASEB J. 2019.
PMID: 30951375
We have elucidated an important role for the cytotoxic immune effector molecule perforin from CD8 T cells in restricting hepatic inflammation in mice with NASH and suggest that therapies designed to maximize the function of endogenous perforin in CD8 T cells might have potential …
We have elucidated an important role for the cytotoxic immune effector molecule perforin from CD8 T cells in restricting hepatic inflammatio …