Takai T - Search Results

1

In Vitro Human Ion Channel Assays Predictive of Drug Induced Seizure.

Cohen JD, You D, Sharma AK, Takai T, Hara H, Sales VT, Yukawa T, Cai B. Cohen JD, et al. Among authors: takai t. Toxicol Sci. 2024 Dec 11:kfae148. doi: 10.1093/toxsci/kfae148. Online ahead of print. Toxicol Sci. 2024. PMID: 39661496

2

Practical application of 3-substituted-2,6-difluoropyridines in drug discovery: Facile synthesis of novel protein kinase C theta inhibitors.

Katoh T, Tomata Y, Setoh M, Sasaki S, Takai T, Yoshitomi Y, Yukawa T, Nakagawa H, Fukumoto S, Tsukamoto T, Nakada Y. Katoh T, et al. Among authors: takai t. Bioorg Med Chem Lett. 2017 Jun 1;27(11):2497-2501. doi: 10.1016/j.bmcl.2017.03.099. Epub 2017 Apr 2. Bioorg Med Chem Lett. 2017. PMID: 28400232

3

Discovery of a novel B-cell lymphoma 6 (BCL6)-corepressor interaction inhibitor by utilizing structure-based drug design.

Yasui T, Yamamoto T, Sakai N, Asano K, Takai T, Yoshitomi Y, Davis M, Takagi T, Sakamoto K, Sogabe S, Kamada Y, Lane W, Snell G, Iwata M, Goto M, Inooka H, Sakamoto JI, Nakada Y, Imaeda Y. Yasui T, et al. Among authors: takai t. Bioorg Med Chem. 2017 Sep 1;25(17):4876-4886. doi: 10.1016/j.bmc.2017.07.037. Epub 2017 Jul 20. Bioorg Med Chem. 2017. PMID: 28760529

4

Discovery of a Potent and Orally Bioavailable Melatonin Receptor Agonist.

Hoashi Y, Takai T, Kosugi Y, Nakashima M, Nakayama M, Hirai K, Uchikawa O, Koike T. Hoashi Y, et al. Among authors: takai t. J Med Chem. 2021 Mar 25;64(6):3059-3074. doi: 10.1021/acs.jmedchem.0c01836. Epub 2021 Mar 7. J Med Chem. 2021. PMID: 33682410

5

Structure-based design, synthesis, and biological evaluation of imidazo[1,2-b]pyridazine-based p38 MAP kinase inhibitors.

Kaieda A, Takahashi M, Takai T, Goto M, Miyazaki T, Hori Y, Unno S, Kawamoto T, Tanaka T, Itono S, Takagi T, Hamada T, Shirasaki M, Okada K, Snell G, Bragstad K, Sang BC, Uchikawa O, Miwatashi S. Kaieda A, et al. Among authors: takai t. Bioorg Med Chem. 2018 Feb 1;26(3):647-660. doi: 10.1016/j.bmc.2017.12.031. Epub 2017 Dec 24. Bioorg Med Chem. 2018. PMID: 29291937

6

Discovery and optimization of 1,7-disubstituted-2,2-dimethyl-2,3-dihydroquinazolin-4(1H)-ones as potent and selective PKCθ inhibitors.

Katoh T, Takai T, Yukawa T, Tsukamoto T, Watanabe E, Mototani H, Arita T, Hayashi H, Nakagawa H, Klein MG, Zou H, Sang BC, Snell G, Nakada Y. Katoh T, et al. Among authors: takai t. Bioorg Med Chem. 2016 Jun 1;24(11):2466-2475. doi: 10.1016/j.bmc.2016.04.008. Epub 2016 Apr 4. Bioorg Med Chem. 2016. PMID: 27117263

7

Design and synthesis of piperazine derivatives as a novel class of γ-secretase modulators that selectively lower Aβ₄₂ production.

Takai T, Koike T, Honda E, Kajita Y, Nakamura M, Morimoto S, Hoashi Y, Kamata M, Watanabe T, Igari T, Terauchi J. Takai T, et al. Bioorg Med Chem. 2015 May 1;23(9):1923-34. doi: 10.1016/j.bmc.2015.03.055. Epub 2015 Mar 28. Bioorg Med Chem. 2015. PMID: 25842363

8

Discovery of novel 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine derivatives as γ-secretase modulators.

Takai T, Hoashi Y, Tomata Y, Morimoto S, Nakamura M, Watanabe T, Igari T, Koike T. Takai T, et al. Bioorg Med Chem Lett. 2015 Oct 1;25(19):4245-9. doi: 10.1016/j.bmcl.2015.07.101. Epub 2015 Aug 7. Bioorg Med Chem Lett. 2015. PMID: 26298496

9

Discovery of 1,2,3,4-tetrahydropyrimido[1,2-a]benzimidazoles as novel class of corticotropin releasing factor 1 receptor antagonists.

Kojima T, Mochizuki M, Takai T, Hoashi Y, Morimoto S, Seto M, Nakamura M, Kobayashi K, Sako Y, Tanaka M, Kanzaki N, Kosugi Y, Yano T, Aso K. Kojima T, et al. Among authors: takai t. Bioorg Med Chem. 2018 May 15;26(9):2229-2250. doi: 10.1016/j.bmc.2018.01.020. Epub 2018 Feb 8. Bioorg Med Chem. 2018. PMID: 29459145

10

Discovery of novel 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine derivatives as γ-secretase modulators (Part 2).

Takai T, Koike T, Nakamura M, Kajita Y, Yamashita T, Taya N, Tsukamoto T, Watanabe T, Murakami K, Igari T, Kamata M. Takai T, et al. Bioorg Med Chem. 2016 Jul 15;24(14):3192-206. doi: 10.1016/j.bmc.2016.05.040. Epub 2016 May 20. Bioorg Med Chem. 2016. PMID: 27255179

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