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A Putative Frizzled 7-Targeting Compound Acts as a Firefly Luciferase Inhibitor.
Kinsolving J, Grätz L, Voss JH, Löw B, Shorter E, Jude B, Lanner JT, Löber S, Gmeiner P, Schulte G. Kinsolving J, et al. Among authors: schulte g. J Med Chem. 2024 Dec 26;67(24):22332-22341. doi: 10.1021/acs.jmedchem.4c02766. Epub 2024 Dec 13. J Med Chem. 2024. PMID: 39670643 Free PMC article.
Frizzleds act as dynamic pharmacological entities.
Schulte G, Scharf MM, Bous J, Voss JH, Grätz L, Kozielewicz P. Schulte G, et al. Trends Pharmacol Sci. 2024 May;45(5):419-429. doi: 10.1016/j.tips.2024.03.003. Epub 2024 Apr 8. Trends Pharmacol Sci. 2024. PMID: 38594145 Free article. Review.
Structural basis of frizzled 7 activation and allosteric regulation.
Bous J, Kinsolving J, Grätz L, Scharf MM, Voss JH, Selcuk B, Adebali O, Schulte G. Bous J, et al. Among authors: schulte g. Nat Commun. 2024 Aug 28;15(1):7422. doi: 10.1038/s41467-024-51664-4. Nat Commun. 2024. PMID: 39198452 Free PMC article.
A molecular mechanism to diversify Ca2+ signaling downstream of Gs protein-coupled receptors.
Brands J, Bravo S, Jürgenliemke L, Grätz L, Schihada H, Frechen F, Alenfelder J, Pfeil C, Ohse PG, Hiratsuka S, Kawakami K, Schmacke LC, Heycke N, Inoue A, König G, Pfeifer A, Wachten D, Schulte G, Steinmetzer T, Watts VJ, Gomeza J, Simon K, Kostenis E. Brands J, et al. Among authors: schulte g. Nat Commun. 2024 Sep 3;15(1):7684. doi: 10.1038/s41467-024-51991-6. Nat Commun. 2024. PMID: 39227390 Free PMC article.
eGFP-tagged Wnt-3a enables functional analysis of Wnt trafficking and signaling and kinetic assessment of Wnt binding to full-length Frizzled.
Wesslowski J, Kozielewicz P, Wang X, Cui H, Schihada H, Kranz D, Karuna M P, Levkin P, Gross JC, Boutros M, Schulte G, Davidson G. Wesslowski J, et al. Among authors: schulte g. J Biol Chem. 2020 Jun 26;295(26):8759-8774. doi: 10.1074/jbc.RA120.012892. Epub 2020 May 7. J Biol Chem. 2020. PMID: 32381507 Free PMC article.
188 results