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Page 1
The impact of inactivation of the GH/IGF axis during aging on healthspan.
Poudel SB, Ruff RR, He Z, Dixit M, Yildirim G, Jayarathne H, Manchanayake DH, Basta-Pljakic J, Duran-Ortiz S, Schaffler MB, Kopchick JJ, Sadagurski M, Yakar S. Poudel SB, et al. Among authors: jayarathne h. Geroscience. 2024 Nov 13. doi: 10.1007/s11357-024-01426-3. Online ahead of print. Geroscience. 2024. PMID: 39535693
Hypothalamic sex-specific metabolic shift by canagliflozin during aging.
Jayarathne HSM, Sullivan R, Stilgenbauer L, Debarba LK, Kuchumov A, Koshko L, Scofield S, Liu W, Ginsburg BC, Miller RA, Sadagurski M. Jayarathne HSM, et al. Geroscience. 2024 Oct;46(5):4479-4493. doi: 10.1007/s11357-024-01214-z. Epub 2024 May 27. Geroscience. 2024. PMID: 38801647 Free PMC article.
Microglial NF-κB Signaling Deficiency Protects Against Metabolic Disruptions Caused by Volatile Organic Compound via Modulating the Hypothalamic Transcriptome.
Debarba LK, Jayarathne HSM, Stilgenbauer L, Terra Dos Santos AL, Koshko L, Scofield S, Sullivan R, Mandal A, Klueh U, Sadagurski M. Debarba LK, et al. Among authors: jayarathne hsm. bioRxiv [Preprint]. 2023 Nov 13:2023.11.08.566279. doi: 10.1101/2023.11.08.566279. bioRxiv. 2023. PMID: 38014216 Free PMC article. Preprint.
Repurposing Canagliflozin to target brain aging.
Jayarathne H, Liu W, Sadagurski M. Jayarathne H, et al. Aging (Albany NY). 2023 Mar 24;15(7):2367-2368. doi: 10.18632/aging.204624. Epub 2023 Mar 24. Aging (Albany NY). 2023. PMID: 36971696 Free PMC article. No abstract available.
Prenatal benzene exposure alters offspring hypothalamic development predisposing to metabolic disease in later life.
Koshko L, Scofield S, Debarba L, Stilgenbauer L, Sacla M, Fakhoury P, Jayarathne H, Perez-Mojica JE, Griggs E, Lempradl A, Sadagurski M. Koshko L, et al. Among authors: jayarathne h. bioRxiv [Preprint]. 2023 Jan 5:2023.01.05.522910. doi: 10.1101/2023.01.05.522910. bioRxiv. 2023. Update in: Chemosphere. 2023 Jul;330:138738. doi: 10.1016/j.chemosphere.2023.138738 PMID: 36711607 Free PMC article. Updated. Preprint.
Canagliflozin retards age-related lesions in heart, kidney, liver, and adrenal gland in genetically heterogenous male mice.
Snyder JM, Casey KM, Galecki A, Harrison DE, Jayarathne H, Kumar N, Macchiarini F, Rosenthal N, Sadagurski M, Salmon AB, Strong R, Miller RA, Ladiges W. Snyder JM, et al. Among authors: jayarathne h. Geroscience. 2023 Feb;45(1):385-397. doi: 10.1007/s11357-022-00641-0. Epub 2022 Aug 16. Geroscience. 2023. PMID: 35974129 Free PMC article.
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