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A multidonor class of highly glycan-dependent HIV-1 gp120-gp41 interface-targeting broadly neutralizing antibodies.
Cale EM, Shen CH, Olia AS, Radakovich NA, Rawi R, Yang Y, Ambrozak DR, Bennici AK, Chuang GY, Crooks ED, Driscoll JI, Lin BC, Louder MK, Madden PJ, Messina MA, Osawa K, Stewart-Jones GBE, Verardi R, Vrakas Z, Xie D, Zhang B, Binley JM, Connors M, Koup RA, Pierson TC, Doria-Rose NA, Kwong PD, Mascola JR, Gorman J. Cale EM, et al. Among authors: pierson tc. Cell Rep. 2024 Dec 24;43(12):115010. doi: 10.1016/j.celrep.2024.115010. Epub 2024 Dec 14. Cell Rep. 2024. PMID: 39675002 Free article.
Long trimer-immunization interval and appropriate adjuvant reduce immune responses to the soluble HIV-1-envelope trimer base.
Duan H, Corrigan AR, Cheng C, Biju A, Gonelli CA, Olia AS, Teng IT, Xu K, O'Dell S, Narpala S, Castro M, Serebryannyy L, Wang J, Parchment DK, Sarfo EK, van Schooten J, Todd JP, Wang S, Harris DR, Geng H, Jafari AJ; VRC Production Program; Woodward RA, Doria-Rose NA, Foulds KE, McDermott AB, van Gils MJ, Koup RA, Pierson TC, Kwong PD, Mascola JR. Duan H, et al. Among authors: pierson tc. iScience. 2024 Jan 11;27(2):108877. doi: 10.1016/j.isci.2024.108877. eCollection 2024 Feb 16. iScience. 2024. PMID: 38318357 Free PMC article.
Potent and broad HIV-1 neutralization in fusion peptide-primed SHIV-infected macaques.
Wang H, Cheng C, Dal Santo JL, Shen CH, Bylund T, Henry AR, Howe CA, Hwang J, Morano NC, Morris DJ, Pletnev S, Roark RS, Zhou T, Hansen BT, Hoyt FH, Johnston TS, Wang S, Zhang B, Ambrozak DR, Becker JE, Bender MF, Changela A, Chaudhary R, Corcoran M, Corrigan AR, Foulds KE, Guo Y, Lee M, Li Y, Lin BC, Liu T, Louder MK, Mandolesi M, Mason RD, McKee K, Nair V, O'Dell S, Olia AS, Ou L, Pegu A, Raju N, Rawi R, Roberts-Torres J, Sarfo EK, Sastry M, Schaub AJ, Schmidt SD, Schramm CA, Schwartz CL, Smith SC, Stephens T, Stuckey J, Teng IT, Todd JP, Tsybovsky Y, Van Wazer DJ, Wang S, Doria-Rose NA, Fischer ER, Georgiev IS, Karlsson Hedestam GB, Sheng Z, Woodward RA, Douek DC, Koup RA, Pierson TC, Shapiro L, Shaw GM, Mascola JR, Kwong PD. Wang H, et al. Among authors: pierson tc. Cell. 2024 Dec 12;187(25):7214-7231.e23. doi: 10.1016/j.cell.2024.10.003. Epub 2024 Oct 28. Cell. 2024. PMID: 39471811
pr-independent biogenesis of infectious mature Zika virus particles.
Dowd KA, Schroeder M, Sanchez E, Brumbaugh B, Foreman BM, Burgomaster KE, Shi W, Wang L, Caputo N, Gordon DN, Schwartz CL, Hansen BT, Aleshnick M, Kong WP, Morabito KM, Hickman HD, Graham BS, Fischer ER, Pierson TC. Dowd KA, et al. Among authors: pierson tc. bioRxiv [Preprint]. 2024 Sep 12:2024.09.12.612520. doi: 10.1101/2024.09.12.612520. bioRxiv. 2024. PMID: 39372759 Free PMC article. Preprint.
Phase 1 dose-escalation trial evaluating a group 2 influenza hemagglutinin stabilized stem nanoparticle vaccine.
Casazza JP, Hofstetter AR, Costner PJM, Holman LA, Hendel CS, Widge AT, Wu RL, Whalen WR, Cunningham J, Arthur A, Wang X, Ola A, Saunders J, Mendoza F, Novik L, Burgos Florez MC, Ortega-Villa AM, Apte PJ, Strom L, Wang L, Imam M, Basappa M, Naisan M, Castro M, Trost JF, Narpala SR, Vanderven HA, Yamshchikov GV, Berkowitz NM, Gordon IJ, Plummer SH, Wycuff DL, Vazquez S, Gillespie RA, Creanga A, Adams WC, Carlton K, Gall JG, McDermott AB, Serebryannyy LA, Houser KV, Koup RA, Graham BS, Ledgerwood JE, Mascola JR, Pierson TC, Andrews SF, Kanekiyo M, Dropulic LK; VRC 323 study team. Casazza JP, et al. Among authors: pierson tc. NPJ Vaccines. 2024 Sep 17;9(1):171. doi: 10.1038/s41541-024-00959-0. NPJ Vaccines. 2024. PMID: 39289377 Free PMC article.
C1q enables influenza hemagglutinin stem binding antibodies to block viral attachment and broadens the antibody escape repertoire.
Kosik I, Da Silva Santos J, Angel M, Hu Z, Holly J, Gibbs JS, Gill T, Kosikova M, Li T, Bakhache W, Dolan PT, Xie H, Andrews SF, Gillespie RA, Kanekiyo M, McDermott AB, Pierson TC, Yewdell JW. Kosik I, et al. Among authors: pierson tc. Sci Immunol. 2024 Mar 22;9(93):eadj9534. doi: 10.1126/sciimmunol.adj9534. Epub 2024 Mar 22. Sci Immunol. 2024. PMID: 38517951
A Prototype-Pathogen Approach for the Development of Flavivirus Countermeasures.
Kuhn RJ, Barrett ADT, Desilva AM, Harris E, Kramer LD, Montgomery RR, Pierson TC, Sette A, Diamond MS. Kuhn RJ, et al. Among authors: pierson tc. J Infect Dis. 2023 Oct 18;228(Suppl 6):S398-S413. doi: 10.1093/infdis/jiad193. J Infect Dis. 2023. PMID: 37849402 Free PMC article. Review.
Viral Prototypes for Pandemic Preparedness: The Road Ahead.
Morabito KM, Cassetti MC, DeRocco AJ, Deschamps AM, Pierson TC. Morabito KM, et al. Among authors: pierson tc. J Infect Dis. 2023 Oct 18;228(Suppl 6):S460-S464. doi: 10.1093/infdis/jiad267. J Infect Dis. 2023. PMID: 37849396 Free PMC article.
148 results