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The zymogenic form of SARS-CoV-2 main protease: A discrete target for drug discovery.
Novotný P, Humpolíčková J, Nováková V, Stanchev S, Stříšovský K, Zgarbová M, Weber J, Kryštůfek R, Starková J, Hradilek M, Moravcová A, Günterová J, Bach K, Majer P, Konvalinka J, Majerová T. Novotný P, et al. Among authors: zgarbova m. J Biol Chem. 2024 Dec 13:108079. doi: 10.1016/j.jbc.2024.108079. Online ahead of print. J Biol Chem. 2024. PMID: 39675720 Free article.
Discovery of highly potent SARS-CoV-2 nsp14 methyltransferase inhibitors based on adenosine 5'-carboxamides.
Kocek H, Chalupská D, Dejmek M, Dvořáková A, Zgarbová M, Šála M, Chalupský K, Krafčíková P, Otava T, Drexler M, Procházková E, Klepetářová B, Štefek M, Kozic J, Mertlíková-Kaiserová H, Boura E, Weber J, Nencka R. Kocek H, et al. Among authors: zgarbova m. RSC Med Chem. 2024 Aug 1;15(10):3469-76. doi: 10.1039/d4md00422a. Online ahead of print. RSC Med Chem. 2024. PMID: 39220762 Free PMC article.
Developing Allosteric Inhibitors of SARS-CoV-2 RNA-Dependent RNA Polymerase.
Chayka A, Danda M, Dostálková A, Spiwok V, Klimešová A, Kapisheva M, Zgarbová M, Weber J, Ruml T, Rumlová M, Janeba Z. Chayka A, et al. Among authors: zgarbova m. ChemMedChem. 2024 Dec 2;19(23):e202400367. doi: 10.1002/cmdc.202400367. Epub 2024 Oct 3. ChemMedChem. 2024. PMID: 39140451 Free PMC article.
Rational Design of Highly Potent SARS-CoV-2 nsp14 Methyltransferase Inhibitors.
Štefek M, Chalupská D, Chalupský K, Zgarbová M, Dvořáková A, Krafčíková P, Li ASM, Šála M, Dejmek M, Otava T, Chaloupecká E, Kozák J, Kozic J, Vedadi M, Weber J, Mertlíková-Kaiserová H, Nencka R. Štefek M, et al. Among authors: zgarbova m. ACS Omega. 2023 Jul 21;8(30):27410-27418. doi: 10.1021/acsomega.3c02815. eCollection 2023 Aug 1. ACS Omega. 2023. PMID: 37546609 Free PMC article.
Ebselen derivatives inhibit SARS-CoV-2 replication by inhibition of its essential proteins: PLpro and Mpro proteases, and nsp14 guanine N7-methyltransferase.
Zmudzinski M, Rut W, Olech K, Granda J, Giurg M, Burda-Grabowska M, Kaleta R, Zgarbova M, Kasprzyk R, Zhang L, Sun X, Lv Z, Nayak D, Kesik-Brodacka M, Olsen SK, Weber J, Hilgenfeld R, Jemielity J, Drag M. Zmudzinski M, et al. Among authors: zgarbova m. Sci Rep. 2023 Jun 6;13(1):9161. doi: 10.1038/s41598-023-35907-w. Sci Rep. 2023. PMID: 37280236 Free PMC article.
43 results