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E-box independent chromatin recruitment turns MYOD into a transcriptional repressor.
Nicoletti C, Massenet J, Pintado-Urbanc AP, Connor LJ, Nicolau M, Sundar S, Xu M, Schmitt A, Zhang W, Fang Z, Chan TCI, Tapscott SJ, Cheung TH, Simon MD, Caputo L, Puri PL. Nicoletti C, et al. Among authors: simon md. bioRxiv [Preprint]. 2024 Dec 5:2024.12.05.627024. doi: 10.1101/2024.12.05.627024. bioRxiv. 2024. PMID: 39677796 Free PMC article. Preprint.
Acetyl-methyllysine marks chromatin at active transcription start sites.
Lu-Culligan WJ, Connor LJ, Xie Y, Ekundayo BE, Rose BT, Machyna M, Pintado-Urbanc AP, Zimmer JT, Vock IW, Bhanu NV, King MC, Garcia BA, Bleichert F, Simon MD. Lu-Culligan WJ, et al. Among authors: simon md. Nature. 2023 Oct;622(7981):173-179. doi: 10.1038/s41586-023-06565-9. Epub 2023 Sep 20. Nature. 2023. PMID: 37731000 Free PMC article.
Targeted Degradation of mRNA Decapping Enzyme DcpS by a VHL-Recruiting PROTAC.
Swartzel JC, Bond MJ, Pintado-Urbanc AP, Daftary M, Krone MW, Douglas T, Carder EJ, Zimmer JT, Maeda T, Simon MD, Crews CM. Swartzel JC, et al. Among authors: simon md. ACS Chem Biol. 2022 Jul 15;17(7):1789-1798. doi: 10.1021/acschembio.2c00145. Epub 2022 Jun 24. ACS Chem Biol. 2022. PMID: 35749470 Free PMC article.
Transcription elongation defects link oncogenic splicing factor mutations to targetable alterations in chromatin landscape.
Boddu PC, Gupta A, Roy R, De La Pena Avalos B, Herrero AO, Neuenkirchen N, Zimmer J, Chandhok N, King D, Nannya Y, Ogawa S, Lin H, Simon M, Dray E, Kupfer G, Verma AK, Neugebauer KM, Pillai MM. Boddu PC, et al. bioRxiv [Preprint]. 2023 Feb 26:2023.02.25.530019. doi: 10.1101/2023.02.25.530019. bioRxiv. 2023. Update in: Mol Cell. 2024 Apr 18;84(8):1475-1495.e18. doi: 10.1016/j.molcel.2024.02.032 PMID: 36891287 Free PMC article. Updated. Preprint.
Rapid folding of nascent RNA regulates eukaryotic RNA biogenesis.
Schärfen L, Vock IW, Simon MD, Neugebauer KM. Schärfen L, et al. Among authors: simon md. bioRxiv [Preprint]. 2024 Nov 26:2024.11.26.625435. doi: 10.1101/2024.11.26.625435. bioRxiv. 2024. PMID: 39651172 Free PMC article. Preprint.
105 results