Achuthan V - Search Results

1

Disruption of LEDGF/p75-directed integration derepresses antisense transcription of the HIV-1 genome.

Tedbury PR, Mahboubi D, Puray-Chavez M, Shah R, Ukah OB, Wahoski CC, Fadel HJ, Poeschla EM, Gao X, McFadden WM, Gaitanidou M, Kesesidis N, Kirby KA, Vanderford TH, Kvaratskhelia M, Achuthan V, Behrens RT, Engelman AN, Sarafianos SG. Tedbury PR, et al. Among authors: achuthan v. bioRxiv [Preprint]. 2024 Dec 6:2024.12.06.627169. doi: 10.1101/2024.12.06.627169. bioRxiv. 2024. PMID: 39677798 Free PMC article. Preprint.

2

Genome-wide CRISPR/Cas9 transcriptional activation screen identifies a histone acetyltransferase inhibitor complex as a regulator of HIV-1 integration.

Zhang Q, Wang S, Li W, Yau E, Hui H, Singh PK, Achuthan V, Young Karris MA, Engelman AN, Rana TM. Zhang Q, et al. Among authors: achuthan v. Nucleic Acids Res. 2022 Jul 8;50(12):6687-6701. doi: 10.1093/nar/gkac464. Nucleic Acids Res. 2022. PMID: 35713529 Free PMC article.

3

Physiological magnesium concentrations increase fidelity of diverse reverse transcriptases from HIV-1, HIV-2, and foamy virus, but not MuLV or AMV.

Wang R, Belew AT, Achuthan V, El Sayed N, DeStefano JJ. Wang R, et al. Among authors: achuthan v. J Gen Virol. 2021 Dec;102(12):001708. doi: 10.1099/jgv.0.001708. J Gen Virol. 2021. PMID: 34904939 Free PMC article.

4

Intra- and extra-cellular environments contribute to the fate of HIV-1 infection.

Ratnapriya S, Harris M, Chov A, Herbert ZT, Vrbanac V, Deruaz M, Achuthan V, Engelman AN, Sodroski J, Herschhorn A. Ratnapriya S, et al. Among authors: achuthan v. Cell Rep. 2021 Aug 31;36(9):109622. doi: 10.1016/j.celrep.2021.109622. Cell Rep. 2021. PMID: 34469717 Free PMC article.

5

Publisher Correction: HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains.

Francis AC, Marin M, Singh PK, Achuthan V, Prellberg MJ, Palermino-Rowland K, Lan S, Tedbury PR, Sarafianos SG, Engelman AN, Melikyan GB. Francis AC, et al. Among authors: achuthan v. Nat Commun. 2020 Nov 26;11(1):6165. doi: 10.1038/s41467-020-20152-w. Nat Commun. 2020. PMID: 33244008 Free PMC article.

6

CPSF6-Dependent Targeting of Speckle-Associated Domains Distinguishes Primate from Nonprimate Lentiviral Integration.

Li W, Singh PK, Sowd GA, Bedwell GJ, Jang S, Achuthan V, Oleru AV, Wong D, Fadel HJ, Lee K, KewalRamani VN, Poeschla EM, Herschhorn A, Engelman AN. Li W, et al. Among authors: achuthan v. mBio. 2020 Sep 29;11(5):e02254-20. doi: 10.1128/mBio.02254-20. mBio. 2020. PMID: 32994325 Free PMC article.

7

HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains.

Francis AC, Marin M, Singh PK, Achuthan V, Prellberg MJ, Palermino-Rowland K, Lan S, Tedbury PR, Sarafianos SG, Engelman AN, Melikyan GB. Francis AC, et al. Among authors: achuthan v. Nat Commun. 2020 Jul 14;11(1):3505. doi: 10.1038/s41467-020-17256-8. Nat Commun. 2020. PMID: 32665593 Free PMC article.

8

Disrupting MLV integrase:BET protein interaction biases integration into quiescent chromatin and delays but does not eliminate tumor activation in a MYC/Runx2 mouse model.

Loyola L, Achuthan V, Gilroy K, Borland G, Kilbey A, Mackay N, Bell M, Hay J, Aiyer S, Fingerman D, Villanueva RA, Cameron E, Kozak CA, Engelman AN, Neil J, Roth MJ. Loyola L, et al. Among authors: achuthan v. PLoS Pathog. 2019 Dec 9;15(12):e1008154. doi: 10.1371/journal.ppat.1008154. eCollection 2019 Dec. PLoS Pathog. 2019. PMID: 31815961 Free PMC article.

9

Capsid-CPSF6 interaction: Master regulator of nuclear HIV-1 positioning and integration.

Achuthan V, Perreira JM, Ahn JJ, Brass AL, Engelman AN. Achuthan V, et al. J Life Sci (Westlake Village). 2019 Jun;1(1):39-45. doi: 10.36069/jols/20190604. J Life Sci (Westlake Village). 2019. PMID: 31448372 Free PMC article.

10

Capsid-CPSF6 Interaction Licenses Nuclear HIV-1 Trafficking to Sites of Viral DNA Integration.

Achuthan V, Perreira JM, Sowd GA, Puray-Chavez M, McDougall WM, Paulucci-Holthauzen A, Wu X, Fadel HJ, Poeschla EM, Multani AS, Hughes SH, Sarafianos SG, Brass AL, Engelman AN. Achuthan V, et al. Cell Host Microbe. 2018 Sep 12;24(3):392-404.e8. doi: 10.1016/j.chom.2018.08.002. Epub 2018 Aug 30. Cell Host Microbe. 2018. PMID: 30173955 Free PMC article.

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