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178 results

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Page 1
Ancestral Genomic Functional Differences in Oligodendroglia: Implications for Alzheimer's Disease.
Ramirez AM, Bertholim-Nasciben L, Moura S, Coombs LE, Rajabli F, DeRosa BA, Whitehead PG, Adams LD, Starks TD, Mena P, Illannes-Manrique M, Tejada SJ, Byrd GS, Caban-Holt A, Cuccaro M, McInerney K, Cornejo-Olivas M, Feliciano-Astacio B, Wang L, Robayo MC, Xu W, Jin F, Pericak-Vance MA, Griswold AJ, Dykxhoorn DM, Young JI, Vance JM. Ramirez AM, et al. Among authors: cuccaro m. Res Sq [Preprint]. 2024 Dec 4:rs.3.rs-5338140. doi: 10.21203/rs.3.rs-5338140/v1. Res Sq. 2024. PMID: 39678342 Free PMC article. Preprint.
African origin haplotype protective for Alzheimer's disease in APOEε4 carriers: exploring potential mechanisms.
Bertholim-Nasciben L, Nuytemans K, Van Booven D, Rajabli F, Moura S, Ramirez AM, Dykxhoorn DM, Wang L, Scott WK, Davis DA, Vontell RT, McInerney KF, Cuccaro ML, Byrd GS, Haines JL, Gearing M, Adams LD, Pericak-Vance MA; ADSP; Young JI, Griswold AJ, Vance JM. Bertholim-Nasciben L, et al. Among authors: cuccaro ml. bioRxiv [Preprint]. 2024 Oct 27:2024.10.24.619909. doi: 10.1101/2024.10.24.619909. bioRxiv. 2024. PMID: 39484566 Free PMC article. Preprint.
Generalizability of Tau and Amyloid Plasma Biomarkers in Alzheimer's Disease Cohorts of Diverse Genetic Ancestries.
Griswold AJ, Rajabli F, Gu T, Arvizu J, Golightly CG, Whitehead PL, Hamilton-Nelson KL, Adams LD, Sanchez JJ, Mena PR, Starks TD, Illanes-Manrique M, Silva C, Bush WS, Cuccaro ML, Vance JM, Cornejo-Olivas MR, Feliciano-Astacio BE, Byrd GS, Beecham GW, Haines JL, Pericak-Vance MA. Griswold AJ, et al. Among authors: cuccaro ml. medRxiv [Preprint]. 2024 Apr 12:2024.04.10.24305617. doi: 10.1101/2024.04.10.24305617. medRxiv. 2024. PMID: 38645114 Free PMC article. Preprint.
African Ancestry Individuals with Higher Educational Attainment Are Resilient to Alzheimer's Disease Measured by pTau181.
Rajabli F, Seixas AA, Akgun B, Adams LD, Inciute J, Hamilton KL, Whithead PG, Konidari I, Gu T, Arvizu J, Golightly CG, Starks TD, Laux R, Byrd GS, Haines JL, Beecham GW, Griswold AJ, Vance JM, Cuccaro ML, Pericak-Vance MA. Rajabli F, et al. Among authors: cuccaro ml. J Alzheimers Dis. 2024;98(1):221-229. doi: 10.3233/JAD-231116. J Alzheimers Dis. 2024. PMID: 38393909 Free PMC article.
Methylation Clocks Do Not Predict Age or Alzheimer's Disease Risk Across Genetically Admixed Individuals.
Cruz-González S, Gu E, Gomez L, Mews M, Vance JM, Cuccaro ML, Cornejo-Olivas MR, Feliciano-Astacio BE, Byrd GS, Haines JL, Pericak-Vance MA, Griswold AJ, Bush WS, Capra JA. Cruz-González S, et al. Among authors: cuccaro ml. bioRxiv [Preprint]. 2024 Oct 18:2024.10.16.618588. doi: 10.1101/2024.10.16.618588. bioRxiv. 2024. PMID: 39464059 Free PMC article. Preprint.
An Alzheimer's disease risk variant in TTC3 modifies the actin cytoskeleton organization and the PI3K-Akt signaling pathway in iPSC-derived forebrain neurons.
Cukier HN, Duarte CL, Laverde-Paz MJ, Simon SA, Van Booven DJ, Miyares AT, Whitehead PL, Hamilton-Nelson KL, Adams LD, Carney RM, Cuccaro ML, Vance JM, Pericak-Vance MA, Griswold AJ, Dykxhoorn DM. Cukier HN, et al. Among authors: cuccaro ml. bioRxiv [Preprint]. 2023 May 25:2023.05.25.542316. doi: 10.1101/2023.05.25.542316. bioRxiv. 2023. Update in: Neurobiol Aging. 2023 Nov;131:182-195. doi: 10.1016/j.neurobiolaging.2023.07.007 PMID: 37292815 Free PMC article. Updated. Preprint.
African ancestry APOE e4 non-carriers with higher educational attainment are resilient to Alzheimer disease pathology-specific blood biomarker pTau181.
Rajabli F, Seixas AA, Akgun B, Adams LD, Inciute J, Starks T, Laux R, Byrd GS, Haines JL, Beecham GW, Vance JM, Cuccaro ML, Pericak-Vance MA. Rajabli F, et al. Among authors: cuccaro ml. medRxiv [Preprint]. 2023 Jul 8:2023.07.06.23292263. doi: 10.1101/2023.07.06.23292263. medRxiv. 2023. Update in: J Alzheimers Dis. 2024;98(1):221-229. doi: 10.3233/JAD-231116 PMID: 37461667 Free PMC article. Updated. Preprint.
Novel early-onset Alzheimer-associated genes influence risk through dysregulation of glutamate, immune activation, and intracell signaling pathways.
Cruchaga C, Bradley J, Western D, Wang C, Lucio Da Fonseca E, Neupane A, Kurup J, Ray N, Jean-Francois M, Gorijala P, Bergmann K, Budde J, Martin E, Pericak-Vance M, Cuccaro M, Kunkle B, Morris J, Holtzman D, Perrin R, Naj A, Haines J, Schellenberg G, Fernandez V, Reitz C, Beecham G; Alzheimer’s Disease Genetics Consortium; Charles F. and Joanne Knight Alzheimer’s disease research center Knight ADRC. Cruchaga C, et al. Among authors: cuccaro m. Res Sq [Preprint]. 2024 Jun 5:rs.3.rs-4480585. doi: 10.21203/rs.3.rs-4480585/v1. Res Sq. 2024. PMID: 38883718 Free PMC article. Preprint.
Genetic analysis of cognitive preservation in the midwestern Amish reveals a novel locus on chromosome 2.
Main LR, Song YE, Lynn A, Laux RA, Miskimen KL, Osterman MD, Cuccaro ML, Ogrocki PK, Lerner AJ, Vance JM, Fuzzell MD, Fuzzell SL, Hochstetler SD, Dorfsman DA, Caywood LJ, Prough MB, Adams LD, Clouse JE, Herington SD, Scott WK, Pericak-Vance MA, Haines JL. Main LR, et al. Among authors: cuccaro ml. medRxiv [Preprint]. 2023 Dec 14:2023.12.13.23299932. doi: 10.1101/2023.12.13.23299932. medRxiv. 2023. Update in: Alzheimers Dement. 2024 Nov;20(11):7453-7464. doi: 10.1002/alz.14045 PMID: 38168325 Free PMC article. Updated. Preprint.
Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies LRRC4C, LHX5-AS1 and nominates ancestry-specific loci PTPRK , GRB14 , and KIAA0825 as novel risk loci for Alzheimer's disease: the Alzheimer's Disease Genetics Consortium.
Rajabli F, Benchek P, Tosto G, Kushch N, Sha J, Bazemore K, Zhu C, Lee WP, Haut J, Hamilton-Nelson KL, Wheeler NR, Zhao Y, Farrell JJ, Grunin MA, Leung YY, Kuksa PP, Li D, Lucio da Fonseca E, Mez JB, Palmer EL, Pillai J, Sherva RM, Song YE, Zhang X, Iqbal T, Pathak O, Valladares O, Kuzma AB, Abner E, Adams PM, Aguirre A, Albert MS, Albin RL, Allen M, Alvarez L, Apostolova LG, Arnold SE, Asthana S, Atwood CS, Ayres G, Baldwin CT, Barber RC, Barnes LL, Barral S, Beach TG, Becker JT, Beecham GW, Beekly D, Benitez BA, Bennett D, Bertelson J, Bird TD, Blacker D, Boeve BF, Bowen JD, Boxer A, Brewer J, Burke JR, Burns JM, Buxbaum JD, Cairns NJ, Cantwell LB, Cao C, Carlson CS, Carlsson CM, Carney RM, Carrasquillo MM, Chasse S, Chesselet MF, Chin NA, Chui HC, Chung J, Craft S, Crane PK, Cribbs DH, Crocco EA, Cruchaga C, Cuccaro ML, Cullum M, Darby E, Davis B, De Jager PL, DeCarli C, DeToledo J, Dick M, Dickson DW, Dombroski BA, Doody RS, Duara R, Ertekin-Taner N, Evans DA, Faber KM, Fairchild TJ, Fallon KB, Fardo DW, Farlow MR, Fernandez-Hernandez V, Ferris S, Foroud TM, Frosch MP, Fulton-Howard B, Galasko DR, Gamboa A, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Goate AM, Grabow… See abstract for full author list ➔ Rajabli F, et al. Among authors: cuccaro ml. medRxiv [Preprint]. 2023 Jul 8:2023.07.06.23292311. doi: 10.1101/2023.07.06.23292311. medRxiv. 2023. PMID: 37461624 Free PMC article. Preprint.
178 results