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Page 1
The splicing machinery is dysregulated and represents a therapeutic vulnerability in breast cancer.
Hermán-Sánchez N, G-García ME, Jiménez-Vacas JM, Yubero-Serrano EM, López-Sánchez LM, Romero-Martín S, Raya-Povedano JL, Álvarez-Benito M, Castaño JP, Luque RM, Gahete MD. Hermán-Sánchez N, et al. Among authors: g garcia me. Cell Mol Life Sci. 2024 Dec 27;82(1):18. doi: 10.1007/s00018-024-05515-6. Cell Mol Life Sci. 2024. PMID: 39725737 Free PMC article.
Conditional Pten inactivation in pituitary results in sex-specific prolactinoma formation.
Flores-Martínez Á, Ramos-Herrero VD, Barroso A, Moreno A, G-García ME, Venegas-Moreno E, Dios E, Martínez-Barberá JP, Luque RM, Soto-Moreno A, Cano DA. Flores-Martínez Á, et al. Among authors: g garcia me. Biochim Biophys Acta Mol Basis Dis. 2025 Jan;1871(1):167543. doi: 10.1016/j.bbadis.2024.167543. Epub 2024 Oct 18. Biochim Biophys Acta Mol Basis Dis. 2025. PMID: 39428000
Metformin and simvastatin exert additive antitumour effects in glioblastoma via senescence-state: clinical and translational evidence.
Fuentes-Fayos AC, G-García ME, Pérez-Gómez JM, Montero-Hidalgo AJ, Martín-Colom J, Doval-Rosa C, Blanco-Acevedo C, Torres E, Toledano-Delgado Á, Sánchez-Sánchez R, Peralbo-Santaella E, Ortega-Salas RM, Jiménez-Vacas JM, Tena-Sempere M, López M, Castaño JP, Gahete MD, Solivera J, Luque RM. Fuentes-Fayos AC, et al. Among authors: g garcia me. EBioMedicine. 2023 Apr;90:104484. doi: 10.1016/j.ebiom.2023.104484. Epub 2023 Mar 10. EBioMedicine. 2023. PMID: 36907105 Free PMC article.
Somatostatin Receptor Splicing Variant sst5TMD4 Overexpression in Glioblastoma Is Associated with Poor Survival, Increased Aggressiveness Features, and Somatostatin Analogs Resistance.
Fuentes-Fayos AC, G-García ME, Pérez-Gómez JM, Peel A, Blanco-Acevedo C, Solivera J, Ibáñez-Costa A, Gahete MD, Castaño JP, Luque RM. Fuentes-Fayos AC, et al. Among authors: g garcia me. Int J Mol Sci. 2022 Jan 20;23(3):1143. doi: 10.3390/ijms23031143. Int J Mol Sci. 2022. PMID: 35163067 Free PMC article.
SF3B1 inhibition disrupts malignancy and prolongs survival in glioblastoma patients through BCL2L1 splicing and mTOR/ß-catenin pathways imbalances.
Fuentes-Fayos AC, Pérez-Gómez JM, G-García ME, Jiménez-Vacas JM, Blanco-Acevedo C, Sánchez-Sánchez R, Solivera J, Breunig JJ, Gahete MD, Castaño JP, Luque RM. Fuentes-Fayos AC, et al. Among authors: g garcia me. J Exp Clin Cancer Res. 2022 Jan 27;41(1):39. doi: 10.1186/s13046-022-02241-4. J Exp Clin Cancer Res. 2022. PMID: 35086552 Free PMC article.