Radke MH - Search Results

1

Visualizing sarcomere and cellular dynamics in skeletal muscle to improve cell therapies.

Hüttemeister J, Rudolph F, Radke MH, Fink C, Friedrich D, Preibisch S, Falcke M, Wagner E, Lehnart SE, Gotthardt M. Hüttemeister J, et al. Among authors: radke mh. Elife. 2024 Dec 17;13:e95597. doi: 10.7554/eLife.95597. Elife. 2024. PMID: 39688479 Free PMC article.

2

Titin visualization in real time reveals an unexpected level of mobility within and between sarcomeres.

da Silva Lopes K, Pietas A, Radke MH, Gotthardt M. da Silva Lopes K, et al. Among authors: radke mh. J Cell Biol. 2011 May 16;193(4):785-98. doi: 10.1083/jcb.201010099. Epub 2011 May 9. J Cell Biol. 2011. PMID: 21555460 Free PMC article.

3

Deleting Full Length Titin Versus the Titin M-Band Region Leads to Differential Mechanosignaling and Cardiac Phenotypes.

Radke MH, Polack C, Methawasin M, Fink C, Granzier HL, Gotthardt M. Radke MH, et al. Circulation. 2019 Apr 9;139(15):1813-1827. doi: 10.1161/CIRCULATIONAHA.118.037588. Circulation. 2019. PMID: 30700140 Free PMC article.

4

Deconstructing sarcomeric structure-function relations in titin-BioID knock-in mice.

Rudolph F, Fink C, Hüttemeister J, Kirchner M, Radke MH, Lopez Carballo J, Wagner E, Kohl T, Lehnart SE, Mertins P, Gotthardt M. Rudolph F, et al. Among authors: radke mh. Nat Commun. 2020 Jun 19;11(1):3133. doi: 10.1038/s41467-020-16929-8. Nat Commun. 2020. PMID: 32561764 Free PMC article.

5

Targeted deletion of titin N2B region leads to diastolic dysfunction and cardiac atrophy.

Radke MH, Peng J, Wu Y, McNabb M, Nelson OL, Granzier H, Gotthardt M. Radke MH, et al. Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3444-9. doi: 10.1073/pnas.0608543104. Epub 2007 Feb 20. Proc Natl Acad Sci U S A. 2007. PMID: 17360664 Free PMC article.

6

Deletion of the titin N2B region accelerates myofibrillar force development but does not alter relaxation kinetics.

Elhamine F, Radke MH, Pfitzer G, Granzier H, Gotthardt M, Stehle R. Elhamine F, et al. Among authors: radke mh. J Cell Sci. 2014 Sep 1;127(Pt 17):3666-74. doi: 10.1242/jcs.141796. Epub 2014 Jun 30. J Cell Sci. 2014. PMID: 24982444 Free PMC article.

7

Titin based viscosity in ventricular physiology: an integrative investigation of PEVK-actin interactions.

Chung CS, Methawasin M, Nelson OL, Radke MH, Hidalgo CG, Gotthardt M, Granzier HL. Chung CS, et al. Among authors: radke mh. J Mol Cell Cardiol. 2011 Sep;51(3):428-34. doi: 10.1016/j.yjmcc.2011.06.006. Epub 2011 Jun 16. J Mol Cell Cardiol. 2011. PMID: 21708170 Free PMC article.

8

Reducing RBM20 activity improves diastolic dysfunction and cardiac atrophy.

Hinze F, Dieterich C, Radke MH, Granzier H, Gotthardt M. Hinze F, et al. Among authors: radke mh. J Mol Med (Berl). 2016 Dec;94(12):1349-1358. doi: 10.1007/s00109-016-1483-3. Epub 2016 Nov 26. J Mol Med (Berl). 2016. PMID: 27889803 Free PMC article.

9

Therapeutic inhibition of RBM20 improves diastolic function in a murine heart failure model and human engineered heart tissue.

Radke MH, Badillo-Lisakowski V, Britto-Borges T, Kubli DA, Jüttner R, Parakkat P, Carballo JL, Hüttemeister J, Liss M, Hansen A, Dieterich C, Mullick AE, Gotthardt M. Radke MH, et al. Sci Transl Med. 2021 Dec;13(622):eabe8952. doi: 10.1126/scitranslmed.abe8952. Epub 2021 Dec 1. Sci Transl Med. 2021. PMID: 34851694

10

Drug discovery with an RBM20 dependent titin splice reporter identifies cardenolides as lead structures to improve cardiac filling.

Liss M, Radke MH, Eckhard J, Neuenschwander M, Dauksaite V, von Kries JP, Gotthardt M. Liss M, et al. Among authors: radke mh. PLoS One. 2018 Jun 11;13(6):e0198492. doi: 10.1371/journal.pone.0198492. eCollection 2018. PLoS One. 2018. PMID: 29889873 Free PMC article.

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