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Particulates in CGT guidance survey results - an ISCT process development & manufacturing committee perspective on cell and gene therapy industry knowledge awareness.
Durand N, Davies L, Davies S, McGowan D, Clarke D, Oh S, Sethi D, Werner S, Molina SA; Manufacturing Materials Safety & Technology Working Group (formerly the Particulate Working Group) within the ISCT Process Development & Manufacturing Committee. Durand N, et al. Among authors: mcgowan d. Cytotherapy. 2024 Oct 31:S1465-3249(24)00900-9. doi: 10.1016/j.jcyt.2024.10.004. Online ahead of print. Cytotherapy. 2024. PMID: 39692674
The Discovery and Preclinical Profile of ALG-000184, a Prodrug of the Potent Hepatitis B Virus Capsid Assembly Modulator ALG-001075.
Vendeville S, Amblard F, Bassit L, Beigelman LN, Blatt LM, Chen X, Chou L, Kum DB, Chanda S, Deval J, Geng X, Gupta K, Jekle A, Hu H, Hu X, Kang H, Liu C, Liu J, McGowan DC, Misner DL, Raboisson P, Sanchez AA, Serebryany V, Stoycheva AD, Symons JA, Tan H, Vanrusselt H, Williams C, Welch M, Zhang L, Zhang Q, Zhang Y, Schinazi RF, Smith DB, Debing Y. Vendeville S, et al. Among authors: mcgowan dc. J Med Chem. 2024 Dec 12;67(23):21126-21142. doi: 10.1021/acs.jmedchem.4c01814. Epub 2024 Nov 22. J Med Chem. 2024. PMID: 39575679
Discovery and Preclinical Profile of ALG-055009, a Potent and Selective Thyroid Hormone Receptor Beta (THR-β) Agonist for the Treatment of MASH.
Vandyck K, McGowan DC, Luong XG, Stevens SK, Jekle A, Gupta K, Misner DL, Chanda S, Serebryany V, Welch M, Hu H, Lv Z, Williams C, Maskos K, Lammens A, Stoycheva AD, Lin TI, Blatt LM, Beigelman LN, Symons JA, Raboisson P, Deval J. Vandyck K, et al. Among authors: mcgowan dc. J Med Chem. 2024 Sep 12;67(17):14840-14851. doi: 10.1021/acs.jmedchem.4c01029. Epub 2024 Sep 2. J Med Chem. 2024. PMID: 39221768
Discovery of gem-Dimethyl-hydroxymethylpyridine Derivatives as Potent Non-nucleoside RSV Polymerase Inhibitors.
Grosse S, Cooymans L, Embrechts W, McGowan D, Jacoby E, Stoops B, Gupta K, Ackermann M, Alnajjar S, Guillemont J, Jin Z, Kesteleyn B, Matcha K, Sriboonyapirat P, Truong A, Van Den Berg J, Yu X, Herschke F, Roymans D, Raboisson P, Rigaux P, Jonckers THM. Grosse S, et al. Among authors: mcgowan d. J Med Chem. 2024 Aug 22;67(16):13723-13736. doi: 10.1021/acs.jmedchem.4c00525. Epub 2024 Aug 6. J Med Chem. 2024. PMID: 39105710
Challenges and solutions to system-wide use of precision oncology as the standard of care paradigm.
Lajmi N, Alves-Vasconcelos S, Tsiachristas A, Haworth A, Woods K, Crichton C, Noble T, Salih H, Várnai KA, Branford-White H, Orrell L, Osman A, Bradley KM, Bonney L, McGowan DR, Davies J, Prime MS, Hassan AB. Lajmi N, et al. Among authors: mcgowan dr. Camb Prism Precis Med. 2024 Mar 26;2:e4. doi: 10.1017/pcm.2024.1. eCollection 2024. Camb Prism Precis Med. 2024. PMID: 38699518 Free PMC article. Review.
289 results