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Engineered extrachromosomal oncogene amplifications promote tumorigenesis.
Pradella D, Zhang M, Gao R, Yao MA, Gluchowska KM, Cendon-Florez Y, Mishra T, La Rocca G, Weigl M, Jiao Z, Nguyen HHM, Lisi M, Ozimek MM, Mastroleo C, Chen K, Grimm F, Luebeck J, Zhang S, Zolli AA, Sun EG, Dameracharla B, Zhao Z, Pritykin Y, Sigel C, Chang HY, Mischel PS, Bafna V, Antonescu CR, Ventura A. Pradella D, et al. Among authors: sigel c. Nature. 2024 Dec 18. doi: 10.1038/s41586-024-08318-8. Online ahead of print. Nature. 2024. PMID: 39695225
NIPBL::NACC1 Fusion Hepatic Carcinoma.
Hissong E, Al Assaad M, Bal M, Reed KA, Fornelli A, Levine MF, Gundem G, Semaan A, Orr CE, Sakhadeo U, Manohar J, Sigouros M, Wilkes D, Sboner A, Montgomery EA, Graham RP, Medina-Martínez JS, Robine N, Fang JM, Choi EK, Westerhoff M, Delgado-de la Mora J, Caudell P, Yantiss RK, Papaemmanuil E, Elemento O, Sigel C, Jessurun J, Mosquera JM. Hissong E, et al. Among authors: sigel c. Am J Surg Pathol. 2024 Feb 1;48(2):183-193. doi: 10.1097/PAS.0000000000002159. Epub 2023 Dec 4. Am J Surg Pathol. 2024. PMID: 38047392
Hepatic disease control in patients with intrahepatic cholangiocarcinoma correlates with overall survival.
Soares KC, Jolissaint JS, McIntyre SM, Seier KP, Gönen M, Sigel C, Nasar N, Cercek A, Harding JJ, Kemeny NE, Connell LC, Koerkamp BG, Balachandran VP, D'Angelica MI, Drebin JA, Kingham TP, Wei AC, Jarnagin WR. Soares KC, et al. Among authors: sigel c. Cancer Med. 2023 Jun;12(11):12272-12284. doi: 10.1002/cam4.5925. Epub 2023 Apr 16. Cancer Med. 2023. PMID: 37062071 Free PMC article.
Gemcitabine plus nab-paclitaxel versus FOLFIRINOX for unresected pancreatic cancer: Comparative effectiveness and evaluation of tumor growth in Veterans.
Sigel K, Zhou M, Park YA, Mutetwa T, Nadkarni G, Yeh C, Polak P, Sigel C, Conroy T, Juzyna B, Ychou M, Fojo T, Wisnivesky JP, Bates SE. Sigel K, et al. Among authors: sigel c. Semin Oncol. 2021 Feb;48(1):69-75. doi: 10.1053/j.seminoncol.2021.02.001. Epub 2021 Feb 23. Semin Oncol. 2021. PMID: 33714591 Free PMC article.
Ketohexokinase-mediated fructose metabolism is lost in hepatocellular carcinoma and can be leveraged for metabolic imaging.
Tee SS, Kim N, Cullen Q, Eskandari R, Mamakhanyan A, Srouji RM, Chirayil R, Jeong S, Shakiba M, Kastenhuber ER, Chen S, Sigel C, Lowe SW, Jarnagin WR, Thompson CB, Schietinger A, Keshari KR. Tee SS, et al. Among authors: sigel c. Sci Adv. 2022 Apr 8;8(14):eabm7985. doi: 10.1126/sciadv.abm7985. Epub 2022 Apr 6. Sci Adv. 2022. PMID: 35385296 Free PMC article.
A Novel Approach to Quantify Heterogeneity of Intrahepatic Cholangiocarcinoma: The Hidden-Genome Classifier.
Song Y, Boerner T, Drill E, Shin P, Kumar S, Sigel C, Cercek A, Kemeny N, Abou-Alfa G, Iacobuzio-Donahue C, Cowzer D, Schultz N, Walch H, Balachandran V, Groot Koerkamp B, Kingham P, Soares K, Wei A, D'Angelica M, Drebin J, Chandwani R, Harding JJ, Jarnagin W. Song Y, et al. Among authors: sigel c. Clin Cancer Res. 2024 Aug 15;30(16):3499-3511. doi: 10.1158/1078-0432.CCR-24-0657. Clin Cancer Res. 2024. PMID: 38864854
123 results