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283 results

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Page 1
Resveratrol improves health and survival of mice on a high-calorie diet.
Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, Prabhu VV, Allard JS, Lopez-Lluch G, Lewis K, Pistell PJ, Poosala S, Becker KG, Boss O, Gwinn D, Wang M, Ramaswamy S, Fishbein KW, Spencer RG, Lakatta EG, Le Couteur D, Shaw RJ, Navas P, Puigserver P, Ingram DK, de Cabo R, Sinclair DA. Baur JA, et al. Among authors: sinclair da. Nature. 2006 Nov 16;444(7117):337-42. doi: 10.1038/nature05354. Epub 2006 Nov 1. Nature. 2006. PMID: 17086191 Free PMC article.
Reprogramming to recover youthful epigenetic information and restore vision.
Lu Y, Brommer B, Tian X, Krishnan A, Meer M, Wang C, Vera DL, Zeng Q, Yu D, Bonkowski MS, Yang JH, Zhou S, Hoffmann EM, Karg MM, Schultz MB, Kane AE, Davidsohn N, Korobkina E, Chwalek K, Rajman LA, Church GM, Hochedlinger K, Gladyshev VN, Horvath S, Levine ME, Gregory-Ksander MS, Ksander BR, He Z, Sinclair DA. Lu Y, et al. Among authors: sinclair da. Nature. 2020 Dec;588(7836):124-129. doi: 10.1038/s41586-020-2975-4. Epub 2020 Dec 2. Nature. 2020. PMID: 33268865 Free PMC article.
Mitochondrial and metabolic dysfunction in ageing and age-related diseases.
Amorim JA, Coppotelli G, Rolo AP, Palmeira CM, Ross JM, Sinclair DA. Amorim JA, et al. Among authors: sinclair da. Nat Rev Endocrinol. 2022 Apr;18(4):243-258. doi: 10.1038/s41574-021-00626-7. Epub 2022 Feb 10. Nat Rev Endocrinol. 2022. PMID: 35145250 Free PMC article. Review.
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes.
Milne JC, Lambert PD, Schenk S, Carney DP, Smith JJ, Gagne DJ, Jin L, Boss O, Perni RB, Vu CB, Bemis JE, Xie R, Disch JS, Ng PY, Nunes JJ, Lynch AV, Yang H, Galonek H, Israelian K, Choy W, Iffland A, Lavu S, Medvedik O, Sinclair DA, Olefsky JM, Jirousek MR, Elliott PJ, Westphal CH. Milne JC, et al. Among authors: sinclair da. Nature. 2007 Nov 29;450(7170):712-6. doi: 10.1038/nature06261. Nature. 2007. PMID: 18046409 Free PMC article.
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan.
Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, Wood JG, Zipkin RE, Chung P, Kisielewski A, Zhang LL, Scherer B, Sinclair DA. Howitz KT, et al. Among authors: sinclair da. Nature. 2003 Sep 11;425(6954):191-6. doi: 10.1038/nature01960. Epub 2003 Aug 24. Nature. 2003. PMID: 12939617
Defining a longevity biotechnology company.
Boekstein N, Barzilai N, Bertram A, Betts-LaCroix J, Fortney K, Helliwell SB, Hufford M, Mannick J, McLaughlin J, Mellon J, Morgen E, Regge N, Robinton DA, Sinclair DA, Young S, Starr R, Zhavoronkov A, Peyer J. Boekstein N, et al. Among authors: sinclair da. Nat Biotechnol. 2023 Aug;41(8):1053-1055. doi: 10.1038/s41587-023-01854-0. Nat Biotechnol. 2023. PMID: 37365260 No abstract available.
283 results